DegronMD

Uniprot ID: O96011

Source protein: Peroxisomal membrane protein 11B

Source gene: PEX11B

Class: DEG_APCC_DBOX_1

Location: 124:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7425

ASA_SCORE: 19.8778

COIL: 0.005

CONS_SCORE: 0.5878

DSS_SCORE: 0.0182

HELIX: 0.9936

FCONS_SCORE: 1.2519

RIG_SCORE: 0.9563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R137C	TCGA-D1-A174	UCEC	TCGA	FRYYLFSLI	DEG_APCC_DBOX_1	0.1944
p.A120T	TCGA-EE-A2MR	SKCM	TCGA	FRYYLFSLI	DEG_APCC_DBOX_1	0.2222
p.V114M	TCGA-G4-6302	COAD	TCGA	FRYYLFSLI	DEG_APCC_DBOX_1	0.0556
p.S137F	DO465	BLCA	ICGC	FRYYLFSLI	DEG_APCC_DBOX_1	0.1944
p.M132V	DO5417	BRCA	ICGC	FRYYLFSLI	DEG_APCC_DBOX_1	0.7208
p.M133V	DO231945	LICA	ICGC	FRYYLFSLI	DEG_APCC_DBOX_1	0.3056
p.F124Y	DO229229	THCA	ICGC	FRYYLFSLI	DEG_APCC_DBOX_1	0.6417
p.R123C	DO40900	UCEC	ICGC	FRYYLFSLI	DEG_APCC_DBOX_1	0.3056
p.A120V	SIDM00932	Kidney Carcinoma	GDSC	FRYYLFSLI	DEG_APCC_DBOX_1	0.2222
p.A120V	ACH-000457	Kidney Cancer	CCLE	FRYYLFSLI	DEG_APCC_DBOX_1	0.2222
p.A120V	CAL-54	kidney	COSMIC	FRYYLFSLI	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96011	Peroxisomal membrane protein 11B	DEG_APCC_DBOX_1	124:132	FRYYLFSLI	APC,CDC20,FZR1	0.7425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons