DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: LIG_APCC_ABBA_1

Location: 1593:1598

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9191

ASA_SCORE: 75.6833

COIL: 0.6155

CONS_SCORE: 0.278

DSS_SCORE: 0.4343

HELIX: 0.2262

FCONS_SCORE: 0.8931

RIG_SCORE: 0.7804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1594P	TCGA-A5-A0VP	UCEC	TCGA	FSIHAE	LIG_APCC_ABBA_1	0.6752
p.S1594P	DO42600	UCEC	ICGC	FSIHAE	LIG_APCC_ABBA_1	0.6752
p.I1595V	TCGA-IG-A97I	ESCA	TCGA	FSIHAE	LIG_APCC_ABBA_1	0.5965
p.H1596Q	DO23152	LINC	ICGC	FSIHAE	LIG_APCC_ABBA_1	0.7582
p.H1596Q	DO45081	LINC	ICGC	FSIHAE	LIG_APCC_ABBA_1	0.7582
p.P1583T	ACH-000994	Endometrial/Uterine Cancer	CCLE	FSIHAE	LIG_APCC_ABBA_1	0.0556
p.E1585K	SCH	stomach	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.E1585K	TE-6	oesophagus	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.E1585K	BHY	upper_aerodigestive_tract	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.E1585K	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.E1585K	HuO9	bone	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.E1585K	TC-YIK	cervix	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.E1585K	SAT	upper_aerodigestive_tract	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.G1598C	MDA-MB-231	breast	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.76
p.V1606M	MCC13	skin	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1111
p.P1604H	NCI-H1048	lung	COSMIC	FSIHAE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	LIG_APCC_ABBA_1	1593:1598	FSIHAE	APC,CDC20,FZR1	0.9191	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons