DegronMD

Uniprot ID: Q9NZN8

Source protein: CCR4-NOT transcription complex subunit 2

Source gene: CNOT2

Class: LIG_APCC_ABBA_1

Location: 273:278

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9151

ASA_SCORE: 89.2833

COIL: 0.833

CONS_SCORE: 0.4756

DSS_SCORE: 0.652

HELIX: 0.1133

FCONS_SCORE: 1.1621

RIG_SCORE: 0.7251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S270F	DO50910	LICA	ICGC	FSIHNE	LIG_APCC_ABBA_1	0.25
p.I275V	SIDM00068	Colorectal Carcinoma	GDSC	FSIHNE	LIG_APCC_ABBA_1	0.5965
p.I275V	ACH-002394	Colon/Colorectal Cancer	CCLE	FSIHNE	LIG_APCC_ABBA_1	0.5965
p.I275V	GEO	large_intestine	COSMIC	FSIHNE	LIG_APCC_ABBA_1	0.5965
p.T263I	ACH-000973	Bladder Cancer	CCLE	FSIHNE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZN8	CCR4-NOT transcription complex subunit 2	LIG_APCC_ABBA_1	273:278	FSIHNE	APC,CDC20,FZR1	0.9151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons