DegronMD - Q9NZN8(CNOT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G103S	TCGA-17-Z031	LUAD	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1111
p.G103D	TCGA-34-2596	LUSC	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1111
p.G103D	TCGA-F7-A624	HNSC	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1111
p.G103D	DO44440	HNSC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1111
p.G103D	DO26508	LUSC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1111
p.V110I	TCGA-AX-A0J1	UCEC	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.3056
p.V110I	TCGA-CM-5861	COAD	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.3056
p.V110I	DO7918	COAD	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.3056
p.V110I	DO41199	UCEC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.3056
p.M119I	TCGA-B0-5100	KIRC	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation altering degron motif	0.6507
p.M119I	DO19553	KIRC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation altering degron motif	0.6507
p.Q105K	TCGA-DA-A1I1	SKCM	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1667
p.Q105K	DO37966	SKCM	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1667
p.S101L	TCGA-EO-A22U	UCEC	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation blocking phosphorylation signal	0.5
p.S101L	DO43755	UCEC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation blocking phosphorylation signal	0.5
p.T123M	TCGA-G9-6338	PRAD	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation blocking phosphorylation signal	0.6667
p.T123M	TCGA-VS-A94Z	CESC	TCGA	TPTTGVPTM	DEG_COP1_1	111:119	Mutation blocking phosphorylation signal	0.6667
p.T123M	DO51634	CESC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation blocking phosphorylation signal	0.6667
p.T123M	DO36375	PRAD	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation blocking phosphorylation signal	0.6667
p.R118H	DO48406	BLCA	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation altering degron motif	0.8244
p.R127Q	DO229363	BTCA	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1111
p.S270F	DO50910	LICA	ICGC	FSIHNE	LIG_APCC_ABBA_1	273:278	Mutation rewiring degron network	0.25
p.E125V	DO231165	LUSC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1667
p.P117T	DO27943	ORCA	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation altering degron motif	0.7031
p.P124S	DO46759	PAEN	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1944
p.P124S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1944
p.P124S	ACH-002256	Leukemia	CCLE	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1944
p.P124S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation rewiring degron network	0.1944
p.A111S	DO220011	SARC	ICGC	TPTTGVPTM	DEG_COP1_1	111:119	Mutation altering degron motif	0.7588
p.I275V	SIDM00068	Colorectal Carcinoma	GDSC	FSIHNE	LIG_APCC_ABBA_1	273:278	Mutation altering degron motif	0.5965
p.I275V	ACH-002394	Colon/Colorectal Cancer	CCLE	FSIHNE	LIG_APCC_ABBA_1	273:278	Mutation altering degron motif	0.5965
p.I275V	GEO	large intestine	COSMIC	FSIHNE	LIG_APCC_ABBA_1	273:278	Mutation altering degron motif	0.5965
p.T263I	ACH-000973	Bladder Cancer	CCLE	FSIHNE	LIG_APCC_ABBA_1	273:278	Mutation rewiring degron network	0.0556

Kaplan plot for CNOT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNOT2

UniProt ID: Q9NZN8

Entrez ID: 4848

Protein name: CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNOT2 in