DegronMD

Uniprot ID: Q9NZN8

Source protein: CCR4-NOT transcription complex subunit 2

Source gene: CNOT2

Class: DEG_COP1_1

Location: 111:119

E3 ligase: COP1

DEGRON score: 0.9952

ASA_SCORE: 72.6889

COIL: 0.9109

CONS_SCORE: 0.2705

DSS_SCORE: 0.7128

HELIX: 0.0352

FCONS_SCORE: 0.9622

RIG_SCORE: 0.617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G103S	TCGA-17-Z031	LUAD	TCGA	TPTTGVPTM	DEG_COP1_1	0.1111
p.G103D	TCGA-34-2596	LUSC	TCGA	TPTTGVPTM	DEG_COP1_1	0.1111
p.G103D	TCGA-F7-A624	HNSC	TCGA	TPTTGVPTM	DEG_COP1_1	0.1111
p.G103D	DO44440	HNSC	ICGC	TPTTGVPTM	DEG_COP1_1	0.1111
p.G103D	DO26508	LUSC	ICGC	TPTTGVPTM	DEG_COP1_1	0.1111
p.V110I	TCGA-AX-A0J1	UCEC	TCGA	TPTTGVPTM	DEG_COP1_1	0.3056
p.V110I	TCGA-CM-5861	COAD	TCGA	TPTTGVPTM	DEG_COP1_1	0.3056
p.V110I	DO7918	COAD	ICGC	TPTTGVPTM	DEG_COP1_1	0.3056
p.V110I	DO41199	UCEC	ICGC	TPTTGVPTM	DEG_COP1_1	0.3056
p.M119I	TCGA-B0-5100	KIRC	TCGA	TPTTGVPTM	DEG_COP1_1	0.6507
p.M119I	DO19553	KIRC	ICGC	TPTTGVPTM	DEG_COP1_1	0.6507
p.Q105K	TCGA-DA-A1I1	SKCM	TCGA	TPTTGVPTM	DEG_COP1_1	0.1667
p.Q105K	DO37966	SKCM	ICGC	TPTTGVPTM	DEG_COP1_1	0.1667
p.S101L	TCGA-EO-A22U	UCEC	TCGA	TPTTGVPTM	DEG_COP1_1	0.5
p.S101L	DO43755	UCEC	ICGC	TPTTGVPTM	DEG_COP1_1	0.5
p.T123M	TCGA-G9-6338	PRAD	TCGA	TPTTGVPTM	DEG_COP1_1	0.6667
p.T123M	TCGA-VS-A94Z	CESC	TCGA	TPTTGVPTM	DEG_COP1_1	0.6667
p.T123M	DO51634	CESC	ICGC	TPTTGVPTM	DEG_COP1_1	0.6667
p.T123M	DO36375	PRAD	ICGC	TPTTGVPTM	DEG_COP1_1	0.6667
p.R118H	DO48406	BLCA	ICGC	TPTTGVPTM	DEG_COP1_1	0.8244
p.R127Q	DO229363	BTCA	ICGC	TPTTGVPTM	DEG_COP1_1	0.1111
p.E125V	DO231165	LUSC	ICGC	TPTTGVPTM	DEG_COP1_1	0.1667
p.P117T	DO27943	ORCA	ICGC	TPTTGVPTM	DEG_COP1_1	0.7031
p.P124S	DO46759	PAEN	ICGC	TPTTGVPTM	DEG_COP1_1	0.1944
p.P124S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TPTTGVPTM	DEG_COP1_1	0.1944
p.P124S	ACH-002256	Leukemia	CCLE	TPTTGVPTM	DEG_COP1_1	0.1944
p.P124S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TPTTGVPTM	DEG_COP1_1	0.1944
p.A111S	DO220011	SARC	ICGC	TPTTGVPTM	DEG_COP1_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZN8	CCR4-NOT transcription complex subunit 2	DEG_COP1_1	111:119	TPTTGVPTM	COP1	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TPTTGVPTM

Degron related mutations and impact score

Drug responses associated with CNOT2 mutations

All proteins holding degron of TPTTGVPTM