DegronMD

Uniprot ID: Q05084

Source protein: Islet cell autoantigen 1

Source gene: ICA1

Class: DEG_MDM2_SWIB_1

Location: 390:397

E3 ligase: MDM2

DEGRON score: 0.6507

ASA_SCORE: 62.1125

COIL: 0.1815

CONS_SCORE: 0.423

DSS_SCORE: 0.421

HELIX: 0.8086

FCONS_SCORE: 1.195

RIG_SCORE: 0.7889

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F390L	ACH-000948	Gastric Cancer	CCLE	FSKEWAAV	DEG_MDM2_SWIB_1	0.6981
p.F390L	23132-87	stomach	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	0.6981
p.A396D	TCGA-D7-A6EY	STAD	TCGA	FSKEWAAV	DEG_MDM2_SWIB_1	0.6682
p.E393K	SIDM00032	Bladder Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	0.591
p.E393K	SCaBER	urinary_tract	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	0.591
p.G389S	DO233791	GACA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.3056
p.G389S	DO233952	GACA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.3056
p.F389L	23132-87	stomach	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	0.3056
p.G388D	TCGA-AP-A059	UCEC	TCGA	FSKEWAAV	DEG_MDM2_SWIB_1	0.2778
p.G399A	TCGA-B5-A1MY	UCEC	TCGA	FSKEWAAV	DEG_MDM2_SWIB_1	0.2778
p.L400P	DO233884	GACA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.25
p.G387A	DO43859	UCEC	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.25
p.G401E	DO37699	SKCM	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.2222
p.E402D	DO27128	LUSC	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1944
p.A384D	DO50118	STAD	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1667
p.A383S	SIDM00094	Kidney Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1389
p.A383S	SN12C	kidney	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1389
p.P405L	DO222775	MELA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1111
p.P405L	DO47665	SKCM	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1111
p.G382R	SIDM00135	Breast Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1111
p.G382R	SIDM01131	Small Cell Lung Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1111
p.L405F	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1111
p.L405F	NCI-H2172	lung	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05084	Islet cell autoantigen 1	DEG_MDM2_SWIB_1	390:397	FSKEWAAV	MDM2	0.6507	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons