DegronMD - Q05084(ICA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S350Y	TCGA-90-7964	LUSC	TCGA	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.0833
p.G388D	TCGA-AP-A059	UCEC	TCGA	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.2778
p.G353S	TCGA-AX-A1CE	UCEC	TCGA	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.1667
p.G399A	TCGA-B5-A1MY	UCEC	TCGA	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.2778
p.A396D	TCGA-D7-A6EY	STAD	TCGA	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation altering degron motif	0.6682
p.G389S	DO233791	GACA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.3056
p.G389S	DO233952	GACA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.3056
p.L400P	DO233884	GACA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.25
p.E366D	DO26590	LUSC	ICGC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation altering degron motif	0.6758
p.E402D	DO27128	LUSC	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1944
p.P405L	DO222775	MELA	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1111
p.P405L	DO47665	SKCM	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1111
p.G401E	DO37699	SKCM	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.2222
p.A384D	DO50118	STAD	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1667
p.G387A	DO43859	UCEC	ICGC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.25
p.G376D	DO41361	UCEC	ICGC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.0556
p.G382R	SIDM00135	Breast Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1111
p.G382R	SIDM01131	Small Cell Lung Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1111
p.L405F	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1111
p.L405F	NCI-H2172	lung	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1111
p.A383S	SIDM00094	Kidney Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1389
p.A383S	SN12C	kidney	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.1389
p.E393K	SIDM00032	Bladder Carcinoma	GDSC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation altering degron motif	0.591
p.E393K	SCaBER	urinary tract	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation altering degron motif	0.591
p.D372G	SIDM01709	Melanoma	GDSC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.1667
p.E364K	ACH-000839	Bladder Cancer	CCLE	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation altering degron motif	0.591
p.E364K	SCaBER	urinary tract	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation altering degron motif	0.591
p.L376F	ACH-000924	Lung Cancer	CCLE	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.0556
p.L376F	NCI-H2172	lung	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.0556
p.F390L	ACH-000948	Gastric Cancer	CCLE	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation altering degron motif	0.6981
p.F390L	23132-87	stomach	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation altering degron motif	0.6981
p.A354S	SN12C	kidney	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.1944
p.L375F	NCI-H2172	lung	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.0833
p.L364F	NCI-H2172	lung	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation altering degron motif	0.6981
p.E363K	SCaBER	urinary tract	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation altering degron motif	0.7022
p.F389L	23132-87	stomach	COSMIC	FSKEWAAV	DEG_MDM2_SWIB_1	390:397	Mutation rewiring degron network	0.3056
p.E352K	SCaBER	urinary tract	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.1389
p.A353S	SN12C	kidney	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	359:366	Mutation rewiring degron network	0.1667

Kaplan plot for ICA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ICA1

UniProt ID: Q05084

Entrez ID: 3382

Protein name: Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ICA1 in