DegronMD

Uniprot ID: Q05084

Source protein: Islet cell autoantigen 1

Source gene: ICA1

Class: DEG_SCF_FBW7_2

Location: 359:366

E3 ligase: FBXW7

DEGRON score: 0.9932

ASA_SCORE: 79.7125

COIL: 0.9168

CONS_SCORE: 0.3671

DSS_SCORE: 0.5973

HELIX: 0.0411

FCONS_SCORE: 0.9948

RIG_SCORE: 0.6453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S350Y	TCGA-90-7964	LUSC	TCGA	VAGTPEPE	DEG_SCF_FBW7_2	0.0833
p.G353S	TCGA-AX-A1CE	UCEC	TCGA	VAGTPEPE	DEG_SCF_FBW7_2	0.1667
p.E366D	DO26590	LUSC	ICGC	VAGTPEPE	DEG_SCF_FBW7_2	0.6758
p.G376D	DO41361	UCEC	ICGC	VAGTPEPE	DEG_SCF_FBW7_2	0.0556
p.D372G	SIDM01709	Melanoma	GDSC	VAGTPEPE	DEG_SCF_FBW7_2	0.1667
p.E364K	ACH-000839	Bladder Cancer	CCLE	VAGTPEPE	DEG_SCF_FBW7_2	0.591
p.E364K	SCaBER	urinary_tract	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.591
p.L376F	ACH-000924	Lung Cancer	CCLE	VAGTPEPE	DEG_SCF_FBW7_2	0.0556
p.L376F	NCI-H2172	lung	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.0556
p.A354S	SN12C	kidney	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.1944
p.L375F	NCI-H2172	lung	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.0833
p.L364F	NCI-H2172	lung	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.6981
p.E363K	SCaBER	urinary_tract	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.7022
p.E352K	SCaBER	urinary_tract	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.1389
p.A353S	SN12C	kidney	COSMIC	VAGTPEPE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05084	Islet cell autoantigen 1	DEG_SCF_FBW7_2	359:366	VAGTPEPE	FBXW7	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons