DegronMD

Uniprot ID: P11717

Source protein: Cation-independent mannose-6-phosphate receptor

Source gene: IGF2R

Class: DEG_MDM2_SWIB_1

Location: 904:912

E3 ligase: MDM2

DEGRON score: 0.654

ASA_SCORE: 50.9

COIL: 0.4306

CONS_SCORE: 0.3793

DSS_SCORE: 0.0327

HELIX: 0.0356

FCONS_SCORE: 0.8052

RIG_SCORE: 0.933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N917D	TCGA-EO-A22U	UCEC	TCGA	FSLNWECVV	DEG_MDM2_SWIB_1	0.1944
p.N917D	DO43755	UCEC	ICGC	FSLNWECVV	DEG_MDM2_SWIB_1	0.1944
p.C910R	TCGA-FR-A3YN	SKCM	TCGA	FSLNWECVV	DEG_MDM2_SWIB_1	0.719
p.C910R	DO38111	SKCM	ICGC	FSLNWECVV	DEG_MDM2_SWIB_1	0.719
p.A921S	DO229009	LICA	ICGC	FSLNWECVV	DEG_MDM2_SWIB_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11717	Cation-independent mannose-6-phosphate receptor	DEG_MDM2_SWIB_1	904:912	FSLNWECVV	MDM2	0.654	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons