DegronMD - P11717(IGF2R)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R483P	TCGA-2Z-A9JR	KIRP	TCGA	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.7512
p.R483P	DO219685	KIRP	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.7512
p.V490F	TCGA-AN-A0AK	BRCA	TCGA	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.5957
p.V490F	DO1608	BRCA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.5957
p.V490F	DO229037	LICA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.5957
p.D479N	TCGA-AP-A1DV	UCEC	TCGA	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.25
p.D479N	DO43186	UCEC	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.25
p.N917D	TCGA-EO-A22U	UCEC	TCGA	FSLNWECVV	DEG_MDM2_SWIB_1	904:912	Mutation rewiring degron network	0.1944
p.N917D	DO43755	UCEC	ICGC	FSLNWECVV	DEG_MDM2_SWIB_1	904:912	Mutation rewiring degron network	0.1944
p.C910R	TCGA-FR-A3YN	SKCM	TCGA	FSLNWECVV	DEG_MDM2_SWIB_1	904:912	Mutation altering degron motif	0.719
p.C910R	DO38111	SKCM	ICGC	FSLNWECVV	DEG_MDM2_SWIB_1	904:912	Mutation altering degron motif	0.719
p.E500Q	DO228983	LICA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0556
p.A488S	DO229027	LICA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6477
p.A921S	DO229009	LICA	ICGC	FSLNWECVV	DEG_MDM2_SWIB_1	904:912	Mutation rewiring degron network	0.0833
p.L473I	DO232835	NACA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0833
p.A488T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6028
p.A488T	ACH-000953	Leukemia	CCLE	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6028
p.A488T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6028
p.A477V	SIDM01088	Endometrial Carcinoma	GDSC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944
p.A477V	ACH-000965	Endometrial/Uterine Cancer	CCLE	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944
p.A477V	RL95-2	endometrium	COSMIC	KRYDLSALV	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944

Kaplan plot for IGF2R in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGF2R

UniProt ID: P11717

Entrez ID: 3482

Protein name: Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGF2R in