DegronMD

Uniprot ID: P11717

Source protein: Cation-independent mannose-6-phosphate receptor

Source gene: IGF2R

Class: DEG_APCC_DBOX_1

Location: 482:490

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6791

ASA_SCORE: 36.2889

COIL: 0.2341

CONS_SCORE: 0.5711

DSS_SCORE: 0.3104

HELIX: 0.1507

FCONS_SCORE: 1.3502

RIG_SCORE: 0.8031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R483P	TCGA-2Z-A9JR	KIRP	TCGA	KRYDLSALV	DEG_APCC_DBOX_1	0.7512
p.R483P	DO219685	KIRP	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	0.7512
p.V490F	TCGA-AN-A0AK	BRCA	TCGA	KRYDLSALV	DEG_APCC_DBOX_1	0.5957
p.V490F	DO1608	BRCA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	0.5957
p.V490F	DO229037	LICA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	0.5957
p.D479N	TCGA-AP-A1DV	UCEC	TCGA	KRYDLSALV	DEG_APCC_DBOX_1	0.25
p.D479N	DO43186	UCEC	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	0.25
p.E500Q	DO228983	LICA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	0.0556
p.A488S	DO229027	LICA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	0.6477
p.L473I	DO232835	NACA	ICGC	KRYDLSALV	DEG_APCC_DBOX_1	0.0833
p.A488T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KRYDLSALV	DEG_APCC_DBOX_1	0.6028
p.A488T	ACH-000953	Leukemia	CCLE	KRYDLSALV	DEG_APCC_DBOX_1	0.6028
p.A488T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	KRYDLSALV	DEG_APCC_DBOX_1	0.6028
p.A477V	SIDM01088	Endometrial Carcinoma	GDSC	KRYDLSALV	DEG_APCC_DBOX_1	0.1944
p.A477V	ACH-000965	Endometrial/Uterine Cancer	CCLE	KRYDLSALV	DEG_APCC_DBOX_1	0.1944
p.A477V	RL95-2	endometrium	COSMIC	KRYDLSALV	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11717	Cation-independent mannose-6-phosphate receptor	DEG_APCC_DBOX_1	482:490	KRYDLSALV	APC,CDC20,FZR1	0.6791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons