DegronMD

Uniprot ID: P57737

Source protein: Coronin-7

Source gene: CORO7

Class: LIG_APCC_ABBA_1

Location: 85:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7331

ASA_SCORE: 49.2833

COIL: 0.775

CONS_SCORE: 0.5722

DSS_SCORE: 0.1175

HELIX: 0.0192

FCONS_SCORE: 1.1493

RIG_SCORE: 0.8676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D78E	TCGA-QL-A97D	COAD	TCGA	FSPFDD	LIG_APCC_ABBA_1	0.1389
p.P87S	DO233903	GACA	ICGC	FSPFDD	LIG_APCC_ABBA_1	0.6752
p.D99N	DO11854	GBM	ICGC	FSPFDD	LIG_APCC_ABBA_1	0.0833
p.S82C	DO228390	LICA	ICGC	FSPFDD	LIG_APCC_ABBA_1	0.25
p.H76Y	ACH-000591	Brain Cancer	CCLE	FSPFDD	LIG_APCC_ABBA_1	0.0833
p.D90E	ACH-000879	Endometrial/Uterine Cancer	CCLE	FSPFDD	LIG_APCC_ABBA_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P57737	Coronin-7	LIG_APCC_ABBA_1	85:90	FSPFDD	APC,CDC20,FZR1	0.7331	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons