DegronMD

Uniprot ID: Q6ZS30

Source protein: Neurobeachin-like protein 1

Source gene: NBEAL1

Class: LIG_APCC_ABBA_1

Location: 1407:1412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8508

ASA_SCORE: 83.0333

COIL: 0.8448

CONS_SCORE: 0.281

DSS_SCORE: 0.5788

HELIX: 0.101

FCONS_SCORE: 0.9396

RIG_SCORE: 0.6561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1418I	TCGA-AX-A05Z	UCEC	TCGA	FSVHSD	LIG_APCC_ABBA_1	0.1667
p.T1418I	DO40884	UCEC	ICGC	FSVHSD	LIG_APCC_ABBA_1	0.1667
p.D1420Y	TCGA-BK-A6W3	UCEC	TCGA	FSVHSD	LIG_APCC_ABBA_1	0.1111
p.D1420Y	DO50076	UCEC	ICGC	FSVHSD	LIG_APCC_ABBA_1	0.1111
p.E1414Q	SIDM00971	Breast Carcinoma	GDSC	FSVHSD	LIG_APCC_ABBA_1	0.2778
p.E1414Q	ACH-000828	Breast Cancer	CCLE	FSVHSD	LIG_APCC_ABBA_1	0.2778
p.E1414Q	ZR-75-30	breast	COSMIC	FSVHSD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZS30	Neurobeachin-like protein 1	LIG_APCC_ABBA_1	1407:1412	FSVHSD	APC,CDC20,FZR1	0.8508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons