DegronMD - Q6ZS30(NBEAL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1418I	TCGA-AX-A05Z	UCEC	TCGA	FSVHSD	LIG_APCC_ABBA_1	1407:1412	Mutation rewiring degron network	0.1667
p.T1418I	DO40884	UCEC	ICGC	FSVHSD	LIG_APCC_ABBA_1	1407:1412	Mutation rewiring degron network	0.1667
p.P731H	TCGA-AX-A1CE	UCEC	TCGA	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.2222
p.P731H	DO42280	UCEC	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.2222
p.D1420Y	TCGA-BK-A6W3	UCEC	TCGA	FSVHSD	LIG_APCC_ABBA_1	1407:1412	Mutation rewiring degron network	0.1111
p.D1420Y	DO50076	UCEC	ICGC	FSVHSD	LIG_APCC_ABBA_1	1407:1412	Mutation rewiring degron network	0.1111
p.S751F	TCGA-EE-A2MR	SKCM	TCGA	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.0556
p.S751F	DO37819	SKCM	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.0556
p.R740Q	TCGA-EO-A22R	UCEC	TCGA	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation altering degron motif	0.6218
p.R740Q	DO42713	UCEC	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation altering degron motif	0.6218
p.S748L	DO224968	BRCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.1389
p.S748L	DO227838	BRCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.1389
p.P730Q	DO227549	COCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.1944
p.A750S	DO223086	ESCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation rewiring degron network	0.0833
p.S742P	DO228138	PBCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation blocking phosphorylation signal	0.75
p.E1414Q	SIDM00971	Breast Carcinoma	GDSC	FSVHSD	LIG_APCC_ABBA_1	1407:1412	Mutation rewiring degron network	0.2778
p.E1414Q	ACH-000828	Breast Cancer	CCLE	FSVHSD	LIG_APCC_ABBA_1	1407:1412	Mutation rewiring degron network	0.2778
p.E1414Q	ZR-75-30	breast	COSMIC	FSVHSD	LIG_APCC_ABBA_1	1407:1412	Mutation rewiring degron network	0.2778
p.I736V	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	PITPHRT	DEG_SCF_FBW7_1	735:741	Mutation altering degron motif	0.5965

Kaplan plot for NBEAL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NBEAL1

UniProt ID: Q6ZS30

Entrez ID: 65065

Protein name: Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NBEAL1 in