DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PITPHRT
Uniprot ID:
Q6ZS30
Source protein:
Neurobeachin-like protein 1
Source gene:
NBEAL1
Class:
DEG_SCF_FBW7_1
Location:
735:741
E3 ligase:
FBXW7
DEGRON score:
0.9974
ASA_SCORE:
63.4143
COIL:
0.8121
CONS_SCORE:
0.2905
DSS_SCORE:
0.5979
HELIX:
0.0731
FCONS_SCORE:
1.1155
RIG_SCORE:
0.6746
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P731H
TCGA-AX-A1CE
UCEC
TCGA
PITPHRT
DEG_SCF_FBW7_1
0.2222
p.P731H
DO42280
UCEC
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.2222
p.S751F
TCGA-EE-A2MR
SKCM
TCGA
PITPHRT
DEG_SCF_FBW7_1
0.0556
p.S751F
DO37819
SKCM
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.0556
p.R740Q
TCGA-EO-A22R
UCEC
TCGA
PITPHRT
DEG_SCF_FBW7_1
0.6218
p.R740Q
DO42713
UCEC
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.6218
p.S748L
DO224968
BRCA
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.1389
p.S748L
DO227838
BRCA
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.1389
p.P730Q
DO227549
COCA
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.1944
p.A750S
DO223086
ESCA
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.0833
p.S742P
DO228138
PBCA
ICGC
PITPHRT
DEG_SCF_FBW7_1
0.75
p.I736V
MC-CAR
haematopoietic_and_lymphoid_tissue
COSMIC
PITPHRT
DEG_SCF_FBW7_1
0.5965
Drug responses associated with NBEAL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PITPHRT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZS30
Neurobeachin-like protein 1
DEG_SCF_FBW7_1
735:741
PITPHRT
FBXW7
0.9974
More...