DegronMD

Uniprot ID: Q6ZS30

Source protein: Neurobeachin-like protein 1

Source gene: NBEAL1

Class: DEG_SCF_FBW7_1

Location: 735:741

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 63.4143

COIL: 0.8121

CONS_SCORE: 0.2905

DSS_SCORE: 0.5979

HELIX: 0.0731

FCONS_SCORE: 1.1155

RIG_SCORE: 0.6746

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S742P	DO228138	PBCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.75
p.R740Q	TCGA-EO-A22R	UCEC	TCGA	PITPHRT	DEG_SCF_FBW7_1	0.6218
p.R740Q	DO42713	UCEC	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.6218
p.I736V	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	PITPHRT	DEG_SCF_FBW7_1	0.5965
p.P731H	TCGA-AX-A1CE	UCEC	TCGA	PITPHRT	DEG_SCF_FBW7_1	0.2222
p.P731H	DO42280	UCEC	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.2222
p.P730Q	DO227549	COCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.1944
p.S748L	DO224968	BRCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.1389
p.S748L	DO227838	BRCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.1389
p.A750S	DO223086	ESCA	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.0833
p.S751F	TCGA-EE-A2MR	SKCM	TCGA	PITPHRT	DEG_SCF_FBW7_1	0.0556
p.S751F	DO37819	SKCM	ICGC	PITPHRT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZS30	Neurobeachin-like protein 1	DEG_SCF_FBW7_1	735:741	PITPHRT	FBXW7	0.9974	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons