DegronMD

Uniprot ID: A8K979

Source protein: ERI1 exoribonuclease 2

Source gene: ERI2

Class: LIG_APCC_ABBA_1

Location: 550:555

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 97.0833

COIL: 0.7655

CONS_SCORE: 0.4278

DSS_SCORE: 0.622

HELIX: 0.0205

FCONS_SCORE: 1.0915

RIG_SCORE: 0.7004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A541D	TCGA-AA-3492	COAD	TCGA	FTIHEE	LIG_APCC_ABBA_1	0.0833
p.K552N	DO1094	BRCA	ICGC	FTIHEE	LIG_APCC_ABBA_1	0.6918
p.T564K	DO229031	LICA	ICGC	FTIHEE	LIG_APCC_ABBA_1	0.0833
p.P560Q	DO43154	UCEC	ICGC	FTIHEE	LIG_APCC_ABBA_1	0.1944
p.F544L	DO41133	UCEC	ICGC	FTIHEE	LIG_APCC_ABBA_1	0.1667
p.P544L	SIDM00529	Breast Carcinoma	GDSC	FTIHEE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K979	ERI1 exoribonuclease 2	LIG_APCC_ABBA_1	550:555	FTIHEE	APC,CDC20,FZR1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons