DegronMD

Uniprot ID: P20248

Source protein: Cyclin-A2

Source gene: CCNA2

Class: LIG_APCC_ABBA_1

Location: 99:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9886

ASA_SCORE: 78.75

COIL: 0.6805

CONS_SCORE: 0.3752

DSS_SCORE: 0.5902

HELIX: 0.0365

FCONS_SCORE: 1.176

RIG_SCORE: 0.7781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E105K	TCGA-4Z-AA7W	BLCA	TCGA	FTIHVD	LIG_APCC_ABBA_1	0.3056
p.E105K	DO218984	BLCA	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.3056
p.W90C	TCGA-AP-A1DV	UCEC	TCGA	FTIHVD	LIG_APCC_ABBA_1	0.0833
p.W90C	DO43186	UCEC	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.0833
p.T100A	TCGA-FI-A2D6	UCEC	TCGA	FTIHVD	LIG_APCC_ABBA_1	0.6028
p.T100A	DO43867	UCEC	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.6028
p.A98V	TCGA-IB-7651	PAAD	TCGA	FTIHVD	LIG_APCC_ABBA_1	0.3056
p.A98V	DO233864	GACA	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.3056
p.A98V	DO46657	PAAD	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.3056
p.N93S	DO234238	ESAD	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.1667
p.A98E	DO229028	LICA	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.3056
p.K113Q	DO229047	LICA	ICGC	FTIHVD	LIG_APCC_ABBA_1	0.1944
p.K113Q	SIDM00619	Thyroid Gland Carcinoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	0.1944
p.K113Q	SIDM00579	Neuroblastoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	0.1944
p.P89L	SIDM02059	Colorectal Carcinoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	0.0556
p.K112E	SIDM00793	Burkitt's Lymphoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	0.2222
p.A98G	ACH-000591	Brain Cancer	CCLE	FTIHVD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20248	Cyclin-A2	LIG_APCC_ABBA_1	99:104	FTIHVD	APC,CDC20,FZR1	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons