DegronMD - P20248(CCNA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E105K	TCGA-4Z-AA7W	BLCA	TCGA	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.E105K	DO218984	BLCA	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.W90C	TCGA-AP-A1DV	UCEC	TCGA	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0833
p.W90C	DO43186	UCEC	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0833
p.F152V	TCGA-AX-A0J0	UCEC	TCGA	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1389
p.F152V	DO41133	UCEC	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1389
p.F128C	TCGA-BS-A0UV	UCEC	TCGA	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.0833
p.F128C	DO42793	UCEC	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.0833
p.T100A	TCGA-FI-A2D6	UCEC	TCGA	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.6028
p.T100A	DO43867	UCEC	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation altering degron motif	0.6028
p.A98V	TCGA-IB-7651	PAAD	TCGA	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.A98V	DO233864	GACA	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.A98V	DO46657	PAAD	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.N129K	TCGA-XR-A8TD	LIHC	TCGA	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1111
p.N129K	DO223921	LIHC	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.1111
p.N93S	DO234238	ESAD	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.1667
p.P147T	DO233615	GACA	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation rewiring degron network	0.2778
p.T46N	DO228976	LICA	ICGC	TRAALAVLK	DEG_APCC_DBOX_1	46:54	Mutation altering degron motif	0.5944
p.P137T	DO229019	LICA	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.5919
p.A98E	DO229028	LICA	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.P44T	DO229022	LICA	ICGC	TRAALAVLK	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.2778
p.K113Q	DO229047	LICA	ICGC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation substituting flanking lysine	0.1944
p.K113Q	SIDM00619	Thyroid Gland Carcinoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation substituting flanking lysine	0.1944
p.K113Q	SIDM00579	Neuroblastoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation substituting flanking lysine	0.1944
p.P89L	SIDM02059	Colorectal Carcinoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.0556
p.R138T	SIDM01171	Glioblastoma	GDSC	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.7876
p.R138T	ACH-000571	Brain Cancer	CCLE	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.7876
p.R138T	T98G	central nervous system	COSMIC	PRKPLVPLD	DEG_APCC_DBOX_1	137:145	Mutation altering degron motif	0.7876
p.K112E	SIDM00793	Burkitt's Lymphoma	GDSC	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation substituting flanking lysine	0.2222
p.G60C	SIDM01503	Small Cell Lung Carcinoma	GDSC	TRAALAVLK	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.1667
p.G60C	ACH-000844	Lung Cancer	CCLE	TRAALAVLK	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.1667
p.A98G	ACH-000591	Brain Cancer	CCLE	FTIHVD	LIG_APCC_ABBA_1	99:104	Mutation rewiring degron network	0.3056
p.T46S	ACH-001031	Rhabdoid	CCLE	TRAALAVLK	DEG_APCC_DBOX_1	46:54	Mutation altering degron motif	0.6005

Kaplan plot for CCNA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNA2

UniProt ID: P20248

Entrez ID: 890

Protein name: Cyclin-A2 (Cyclin-A) (Cyclin A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNA2 in