DegronMD

Uniprot ID: P20248

Source protein: Cyclin-A2

Source gene: CCNA2

Class: DEG_APCC_DBOX_1

Location: 137:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.973

ASA_SCORE: 100.9

COIL: 0.9196

CONS_SCORE: 0.3489

DSS_SCORE: 0.4692

HELIX: 0.0269

FCONS_SCORE: 1.0414

RIG_SCORE: 0.6949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F152V	TCGA-AX-A0J0	UCEC	TCGA	PRKPLVPLD	DEG_APCC_DBOX_1	0.1389
p.F152V	DO41133	UCEC	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	0.1389
p.F128C	TCGA-BS-A0UV	UCEC	TCGA	PRKPLVPLD	DEG_APCC_DBOX_1	0.0833
p.F128C	DO42793	UCEC	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	0.0833
p.N129K	TCGA-XR-A8TD	LIHC	TCGA	PRKPLVPLD	DEG_APCC_DBOX_1	0.1111
p.N129K	DO223921	LIHC	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	0.1111
p.P147T	DO233615	GACA	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	0.2778
p.P137T	DO229019	LICA	ICGC	PRKPLVPLD	DEG_APCC_DBOX_1	0.5919
p.R138T	SIDM01171	Glioblastoma	GDSC	PRKPLVPLD	DEG_APCC_DBOX_1	0.7876
p.R138T	ACH-000571	Brain Cancer	CCLE	PRKPLVPLD	DEG_APCC_DBOX_1	0.7876
p.R138T	T98G	central_nervous_system	COSMIC	PRKPLVPLD	DEG_APCC_DBOX_1	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20248	Cyclin-A2	DEG_APCC_DBOX_1	137:145	PRKPLVPLD	APC,CDC20,FZR1	0.973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons