DegronMD

Uniprot ID: P20248

Source protein: Cyclin-A2

Source gene: CCNA2

Class: DEG_APCC_DBOX_1

Location: 46:54

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.932

ASA_SCORE: 73.1

COIL: 0.3212

CONS_SCORE: 0.339

DSS_SCORE: 0.6188

HELIX: 0.6021

FCONS_SCORE: 1.0811

RIG_SCORE: 0.7314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T46N	DO228976	LICA	ICGC	TRAALAVLK	DEG_APCC_DBOX_1	0.5944
p.P44T	DO229022	LICA	ICGC	TRAALAVLK	DEG_APCC_DBOX_1	0.2778
p.G60C	SIDM01503	Small Cell Lung Carcinoma	GDSC	TRAALAVLK	DEG_APCC_DBOX_1	0.1667
p.G60C	ACH-000844	Lung Cancer	CCLE	TRAALAVLK	DEG_APCC_DBOX_1	0.1667
p.T46S	ACH-001031	Rhabdoid	CCLE	TRAALAVLK	DEG_APCC_DBOX_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20248	Cyclin-A2	DEG_APCC_DBOX_1	46:54	TRAALAVLK	APC,CDC20,FZR1	0.932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons