DegronMD

Uniprot ID: O15379

Source protein: Histone deacetylase 3

Source gene: HDAC3

Class: LIG_APCC_ABBA_1

Location: 336:341

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8101

ASA_SCORE: 58.7833

COIL: 0.829

CONS_SCORE: 0.3668

DSS_SCORE: 0.2519

HELIX: 0.0317

FCONS_SCORE: 1.0215

RIG_SCORE: 0.7947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A333G	TCGA-12-0829	GBM	TCGA	FTLHPD	LIG_APCC_ABBA_1	0.25
p.A333G	DO11166	GBM	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.25
p.E347D	TCGA-A5-A0GP	UCEC	TCGA	FTLHPD	LIG_APCC_ABBA_1	0.1667
p.E347D	DO41109	UCEC	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.1667
p.E330K	TCGA-AP-A0LM	UCEC	TCGA	FTLHPD	LIG_APCC_ABBA_1	0.1667
p.E330K	TCGA-EO-A3AV	UCEC	TCGA	FTLHPD	LIG_APCC_ABBA_1	0.1667
p.E330K	DO43306	UCEC	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.1667
p.E330K	DO52412	UCEC	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.1667
p.A333V	TCGA-BR-4184	STAD	TCGA	FTLHPD	LIG_APCC_ABBA_1	0.25
p.A333V	DO38328	STAD	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.25
p.L338F	TCGA-E2-A155	BRCA	TCGA	FTLHPD	LIG_APCC_ABBA_1	0.6981
p.L338F	DO1707	BRCA	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.6981
p.S351L	TCGA-VN-A88I	PRAD	TCGA	FTLHPD	LIG_APCC_ABBA_1	0.0556
p.S351L	DO49854	PRAD	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.0556
p.P340T	DO228948	LICA	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.5919
p.E347K	DO222837	MELA	ICGC	FTLHPD	LIG_APCC_ABBA_1	0.1667
p.R345C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	FTLHPD	LIG_APCC_ABBA_1	0.2222
p.R345C	ACH-000309	Lung Cancer	CCLE	FTLHPD	LIG_APCC_ABBA_1	0.2222
p.R345C	SK-LU-1	lung	COSMIC	FTLHPD	LIG_APCC_ABBA_1	0.2222

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01024	ESCA\|oesophagus	p.V280I (No)	GDSC	Entinostat	110.61
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.D391N (No)	GDSC	Entinostat	3.2022
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.D391N (No)	GDSC	Entinostat	3.2196
SIDM01007	ALL\|lymphoblastic_leukemia	p.F269L (No)	GDSC	Entinostat	0.2839
SIDM01007	ALL\|lymphoblastic_leukemia	p.F269L (No)	GDSC	Entinostat	0.5557
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.K121T (No)	GDSC	Entinostat	28.617
SIDM00216	COREAD\|large_intestine	p.S191P (No)	GDSC	Entinostat	4.6413
SIDM00282	COREAD\|large_intestine	p.R301* (No)	GDSC	Entinostat	3.9412
SIDM00282	COREAD\|large_intestine	p.R301* (No)	GDSC	Entinostat	9.4983
SIDM01179	UNCLASSIFIED\|soft_tissue_other	p.F97L (No)	GDSC	Entinostat	3.2633
SIDM01179	UNCLASSIFIED\|soft_tissue_other	p.F97L (No)	GDSC	Entinostat	79.805
SIDM00534	COREAD\|large_intestine	p.D421Y (No)	GDSC	Entinostat	4.094
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.P23R (No)	GDSC	Entinostat	1.1789
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.P23R (No)	GDSC	Entinostat	8.4086
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.R345C (Yes)	GDSC	Entinostat	656.21
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L384F (No)	GDSC	Entinostat	13.304

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15379	Histone deacetylase 3	LIG_APCC_ABBA_1	336:341	FTLHPD	APC,CDC20,FZR1	0.8101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons