DegronMD

Uniprot ID: P13726

Source protein: Tissue factor

Source gene: F3

Class: LIG_APCC_ABBA_1

Location: 132:137

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8247

ASA_SCORE: 55.3833

COIL: 0.594

CONS_SCORE: 0.6695

DSS_SCORE: 0.531

HELIX: 0.1862

FCONS_SCORE: 1.2544

RIG_SCORE: 0.7988

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F132C	SIDM00534	Colorectal Carcinoma	GDSC	FTPYLE	LIG_APCC_ABBA_1	0.7108
p.F132C	ACH-000986	Colon/Colorectal Cancer	CCLE	FTPYLE	LIG_APCC_ABBA_1	0.7108
p.F132C	HT-115	large_intestine	COSMIC	FTPYLE	LIG_APCC_ABBA_1	0.7108
p.Y135C	TCGA-5M-AAT6	COAD	TCGA	FTPYLE	LIG_APCC_ABBA_1	0.7087
p.Y135C	DO223703	COAD	ICGC	FTPYLE	LIG_APCC_ABBA_1	0.7087
p.S129F	TCGA-FR-A8YE	SKCM	TCGA	FTPYLE	LIG_APCC_ABBA_1	0.25
p.S129F	DO50303	SKCM	ICGC	FTPYLE	LIG_APCC_ABBA_1	0.25
p.G141R	TCGA-AX-A2HD	UCEC	TCGA	FTPYLE	LIG_APCC_ABBA_1	0.2222
p.G141R	DO42608	UCEC	ICGC	FTPYLE	LIG_APCC_ABBA_1	0.2222
p.N128K	DO229035	LICA	ICGC	FTPYLE	LIG_APCC_ABBA_1	0.2222
p.E127D	TCGA-D1-A17Q	UCEC	TCGA	FTPYLE	LIG_APCC_ABBA_1	0.1944
p.E127D	DO41903	UCEC	ICGC	FTPYLE	LIG_APCC_ABBA_1	0.1944
p.Q146K	DO229029	LICA	ICGC	FTPYLE	LIG_APCC_ABBA_1	0.0833

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13726	Tissue factor	LIG_APCC_ABBA_1	132:137	FTPYLE	APC,CDC20,FZR1	0.8247	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons