DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FTPYLE
Uniprot ID:
P13726
Source protein:
Tissue factor
Source gene:
F3
Class:
LIG_APCC_ABBA_1
Location:
132:137
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8247
ASA_SCORE:
55.3833
COIL:
0.594
CONS_SCORE:
0.6695
DSS_SCORE:
0.531
HELIX:
0.1862
FCONS_SCORE:
1.2544
RIG_SCORE:
0.7988
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y135C
TCGA-5M-AAT6
COAD
TCGA
FTPYLE
LIG_APCC_ABBA_1
0.7087
p.Y135C
DO223703
COAD
ICGC
FTPYLE
LIG_APCC_ABBA_1
0.7087
p.G141R
TCGA-AX-A2HD
UCEC
TCGA
FTPYLE
LIG_APCC_ABBA_1
0.2222
p.G141R
DO42608
UCEC
ICGC
FTPYLE
LIG_APCC_ABBA_1
0.2222
p.E127D
TCGA-D1-A17Q
UCEC
TCGA
FTPYLE
LIG_APCC_ABBA_1
0.1944
p.E127D
DO41903
UCEC
ICGC
FTPYLE
LIG_APCC_ABBA_1
0.1944
p.S129F
TCGA-FR-A8YE
SKCM
TCGA
FTPYLE
LIG_APCC_ABBA_1
0.25
p.S129F
DO50303
SKCM
ICGC
FTPYLE
LIG_APCC_ABBA_1
0.25
p.Q146K
DO229029
LICA
ICGC
FTPYLE
LIG_APCC_ABBA_1
0.0833
p.N128K
DO229035
LICA
ICGC
FTPYLE
LIG_APCC_ABBA_1
0.2222
p.F132C
SIDM00534
Colorectal Carcinoma
GDSC
FTPYLE
LIG_APCC_ABBA_1
0.7108
p.F132C
ACH-000986
Colon/Colorectal Cancer
CCLE
FTPYLE
LIG_APCC_ABBA_1
0.7108
p.F132C
HT-115
large_intestine
COSMIC
FTPYLE
LIG_APCC_ABBA_1
0.7108
Drug responses associated with F3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FTPYLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13726
Tissue factor
LIG_APCC_ABBA_1
132:137
FTPYLE
APC,CDC20,FZR1
0.8247
More...