DegronMD - P13726(F3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y135C	TCGA-5M-AAT6	COAD	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation altering degron motif	0.5976
p.Y135C	TCGA-5M-AAT6	COAD	TCGA	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation altering degron motif	0.7087
p.Y135C	DO223703	COAD	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation altering degron motif	0.5976
p.Y135C	DO223703	COAD	ICGC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation altering degron motif	0.7087
p.G141R	TCGA-AX-A2HD	UCEC	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.2222
p.G141R	TCGA-AX-A2HD	UCEC	TCGA	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.G141R	DO42608	UCEC	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.2222
p.G141R	DO42608	UCEC	ICGC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.E127D	TCGA-D1-A17Q	UCEC	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.25
p.E127D	TCGA-D1-A17Q	UCEC	TCGA	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1944
p.E127D	DO41903	UCEC	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.25
p.E127D	DO41903	UCEC	ICGC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1944
p.S129F	TCGA-FR-A8YE	SKCM	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.3056
p.S129F	TCGA-FR-A8YE	SKCM	TCGA	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.25
p.S129F	DO50303	SKCM	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.3056
p.S129F	DO50303	SKCM	ICGC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.25
p.A121D	DO229018	LICA	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.0833
p.Q146K	DO229029	LICA	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.0833
p.Q146K	DO229029	LICA	ICGC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.0833
p.N128K	DO229035	LICA	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation rewiring degron network	0.2778
p.N128K	DO229035	LICA	ICGC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.G281E	SIDM01265	Plasma Cell Myeloma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00683	Prostate Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00377	Other Sarcomas	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00136	Colorectal Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00429	B-Lymphoblastic Leukemia	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00493	Other Solid Cancers	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00907	Burkitt's Lymphoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00431	T-Lymphoblastic Leukemia	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00083	Glioblastoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM01173	Rhabdomyosarcoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.G281E	SIDM00171	Colorectal Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.1944
p.P291S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.3056
p.P291S	SIDM00083	Glioblastoma	GDSC	WKENS	DEG_APCC_KENBOX_2	286:290	Mutation rewiring degron network	0.3056
p.F132C	SIDM00534	Colorectal Carcinoma	GDSC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation altering degron motif	0.5996
p.F132C	SIDM00534	Colorectal Carcinoma	GDSC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation altering degron motif	0.7108
p.F132C	ACH-000986	Colon/Colorectal Cancer	CCLE	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation altering degron motif	0.5996
p.F132C	ACH-000986	Colon/Colorectal Cancer	CCLE	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation altering degron motif	0.7108
p.F132C	HT-115	large intestine	COSMIC	PEFTPYLE	DEG_SCF_FBW7_2	130:137	Mutation altering degron motif	0.5996
p.F132C	HT-115	large intestine	COSMIC	FTPYLE	LIG_APCC_ABBA_1	132:137	Mutation altering degron motif	0.7108

Kaplan plot for F3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

F3

UniProt ID: P13726

Entrez ID: 2152

Protein name: Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for F3 in