DegronMD

Uniprot ID: P13726

Source protein: Tissue factor

Source gene: F3

Class: DEG_APCC_KENBOX_2

Location: 286:290

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7911

ASA_SCORE: 105.96

COIL: 0.9306

CONS_SCORE: 0.3665

DSS_SCORE: 0.4165

HELIX: 0.0254

FCONS_SCORE: 0.8496

RIG_SCORE: 0.7465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G281E	SIDM01265	Plasma Cell Myeloma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00683	Prostate Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00377	Other Sarcomas	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00136	Colorectal Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00429	B-Lymphoblastic Leukemia	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00493	Other Solid Cancers	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00907	Burkitt's Lymphoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00431	T-Lymphoblastic Leukemia	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00083	Glioblastoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM01173	Rhabdomyosarcoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.G281E	SIDM00171	Colorectal Carcinoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.1944
p.P291S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	WKENS	DEG_APCC_KENBOX_2	0.3056
p.P291S	SIDM00083	Glioblastoma	GDSC	WKENS	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13726	Tissue factor	DEG_APCC_KENBOX_2	286:290	WKENS	APC,CDC20,FZR1	0.7911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons