DegronMD

Uniprot ID: P13726

Source protein: Tissue factor

Source gene: F3

Class: DEG_SCF_FBW7_2

Location: 130:137

E3 ligase: FBXW7

DEGRON score: 0.8892

ASA_SCORE: 61.1625

COIL: 0.6515

CONS_SCORE: 0.6273

DSS_SCORE: 0.5223

HELIX: 0.1495

FCONS_SCORE: 1.2262

RIG_SCORE: 0.7822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y135C	TCGA-5M-AAT6	COAD	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	0.5976
p.Y135C	DO223703	COAD	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	0.5976
p.G141R	TCGA-AX-A2HD	UCEC	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	0.2222
p.G141R	DO42608	UCEC	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	0.2222
p.E127D	TCGA-D1-A17Q	UCEC	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	0.25
p.E127D	DO41903	UCEC	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	0.25
p.S129F	TCGA-FR-A8YE	SKCM	TCGA	PEFTPYLE	DEG_SCF_FBW7_2	0.3056
p.S129F	DO50303	SKCM	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	0.3056
p.A121D	DO229018	LICA	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	0.0833
p.Q146K	DO229029	LICA	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	0.0833
p.N128K	DO229035	LICA	ICGC	PEFTPYLE	DEG_SCF_FBW7_2	0.2778
p.F132C	SIDM00534	Colorectal Carcinoma	GDSC	PEFTPYLE	DEG_SCF_FBW7_2	0.5996
p.F132C	ACH-000986	Colon/Colorectal Cancer	CCLE	PEFTPYLE	DEG_SCF_FBW7_2	0.5996
p.F132C	HT-115	large_intestine	COSMIC	PEFTPYLE	DEG_SCF_FBW7_2	0.5996

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13726	Tissue factor	DEG_SCF_FBW7_2	130:137	PEFTPYLE	FBXW7	0.8892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons