DegronMD

Uniprot ID: Q14674

Source protein: Separin

Source gene: ESPL1

Class: LIG_APCC_ABBA_1

Location: 1362:1367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6132

ASA_SCORE: 81.7333

COIL: 0.6495

CONS_SCORE: 0.3237

DSS_SCORE: 0.4597

HELIX: 0.065

FCONS_SCORE: 0.9628

RIG_SCORE: 0.7786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1363M	TCGA-AP-A0LM	UCEC	TCGA	FTVFEE	LIG_APCC_ABBA_1	0.7423
p.T1363M	TCGA-B5-A1MX	UCEC	TCGA	FTVFEE	LIG_APCC_ABBA_1	0.7423
p.T1363M	DO233207	GACA	ICGC	FTVFEE	LIG_APCC_ABBA_1	0.7423
p.T1363M	DO43306	UCEC	ICGC	FTVFEE	LIG_APCC_ABBA_1	0.7423
p.T1363M	DO41999	UCEC	ICGC	FTVFEE	LIG_APCC_ABBA_1	0.7423
p.P1361S	TCGA-QQ-A5VD	SARC	TCGA	FTVFEE	LIG_APCC_ABBA_1	0.3056
p.P1361S	DO222595	MELA	ICGC	FTVFEE	LIG_APCC_ABBA_1	0.3056
p.P1361S	DO220252	SARC	ICGC	FTVFEE	LIG_APCC_ABBA_1	0.3056
p.V1364M	ACH-001970	Metastasis	CCLE	FTVFEE	LIG_APCC_ABBA_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14674	Separin	LIG_APCC_ABBA_1	1362:1367	FTVFEE	APC,CDC20,FZR1	0.6132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons