DegronMD

Uniprot ID: Q86UV5

Source protein: Ubiquitin carboxyl-terminal hydrolase 48

Source gene: USP48

Class: DEG_MDM2_SWIB_1

Location: 749:757

E3 ligase: MDM2

DEGRON score: 0.7702

ASA_SCORE: 49.6111

COIL: 0.0759

CONS_SCORE: 0.4461

DSS_SCORE: 0.067

HELIX: 0.92

FCONS_SCORE: 1.2605

RIG_SCORE: 0.9451

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F748L	TCGA-55-6982	LUAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.3056
p.F748L	DO26280	LUAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.3056
p.P765H	TCGA-AA-3663	COAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.1111
p.P765H	DO9346	COAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.1111
p.T761I	TCGA-AP-A1DK	UCEC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.2222
p.T761I	DO42033	UCEC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.2222
p.R754W	TCGA-C5-A1BL	CESC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.R754W	DO48986	CESC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.R754W	DO228138	PBCA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.R754W	SIDM02015	Colorectal Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.R754W	SIDM00962	Chronic Myelogenous Leukemia	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.R754W	SIDM01080	Oral Cavity Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.R754W	SCC-9	upper_aerodigestive_tract	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.R754W	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7523
p.T739M	TCGA-CG-5730	STAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0556
p.T739M	DO38324	STAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0556
p.R758K	TCGA-D5-6930	COAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.3056
p.R758K	DO10550	COAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.3056
p.F756C	TCGA-EO-A3B0	UCEC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.5996
p.F756C	DO219773	UCEC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.5996
p.R754Q	TCGA-FI-A2D0	UCEC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.6218
p.R754Q	DO43891	UCEC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.6218
p.R754Q	SIDM02035	Colorectal Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.6218
p.Q747K	TCGA-LT-A5Z6	BLCA	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	0.2778
p.Q747K	DO44029	BLCA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.2778
p.Y743C	DO233214	GACA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.1667
p.S764R	DO229026	LICA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.1389
p.V745L	DO232624	PBCA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.2222
p.D740N	SIDM00582	Pancreatic Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0833
p.D740N	KP-2	pancreas	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0833
p.V757F	SIDM01779	Gastric Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.7068
p.R766W	ACH-000181	Head and Neck Cancer	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0833
p.R766W	ACH-000432	Leukemia	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0833
p.R766W	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0833
p.R766W	SCC-9	upper_aerodigestive_tract	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.0833
p.D752N	ACH-000281	Pancreatic Cancer	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	0.6932
p.D752N	KP-2	pancreas	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	0.6932
p.P742L	ACH-001369	Ovarian Cancer	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FVEEWRKFV

Degron related mutations and impact score

Drug responses associated with USP48 mutations

All proteins holding degron of FVEEWRKFV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UV5	Ubiquitin carboxyl-terminal hydrolase 48	DEG_MDM2_SWIB_1	749:757	FVEEWRKFV	MDM2	0.7702	More...