DegronMD - Q86UV5(USP48)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F748L	TCGA-55-6982	LUAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.3056
p.F748L	DO26280	LUAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.3056
p.P765H	TCGA-AA-3663	COAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.1111
p.P765H	DO9346	COAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.1111
p.T761I	TCGA-AP-A1DK	UCEC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.2222
p.T761I	DO42033	UCEC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.2222
p.L651M	TCGA-B5-A11E	UCEC	TCGA	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation altering degron motif	0.5999
p.L651M	DO41644	UCEC	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation altering degron motif	0.5999
p.R754W	TCGA-C5-A1BL	CESC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.R754W	DO48986	CESC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.R754W	DO228138	PBCA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.R754W	SIDM02015	Colorectal Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.R754W	SIDM00962	Chronic Myelogenous Leukemia	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.R754W	SIDM01080	Oral Cavity Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.R754W	SCC-9	upper aerodigestive tract	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.R754W	BV-173	haematopoietic and lymphoid tissue	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7523
p.T739M	TCGA-CG-5730	STAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0556
p.T739M	DO38324	STAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0556
p.R758K	TCGA-D5-6930	COAD	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.3056
p.R758K	DO10550	COAD	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.3056
p.F756C	TCGA-EO-A3B0	UCEC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.5996
p.F756C	DO219773	UCEC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.5996
p.L657V	TCGA-EO-A3B0	UCEC	TCGA	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.3056
p.L657V	DO219773	UCEC	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.3056
p.R754Q	TCGA-FI-A2D0	UCEC	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.6218
p.R754Q	DO43891	UCEC	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.6218
p.R754Q	SIDM02035	Colorectal Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.6218
p.Q747K	TCGA-LT-A5Z6	BLCA	TCGA	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.2778
p.Q747K	DO44029	BLCA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.2778
p.P653S	TCGA-S5-A6DX	BLCA	TCGA	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation altering degron motif	0.6752
p.P653S	DO51903	BLCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation altering degron motif	0.6752
p.P653S	DO51509	PACA	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation altering degron motif	0.6752
p.N645K	TCGA-UZ-A9PS	KIRP	TCGA	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.1667
p.N645K	DO219709	KIRP	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.1667
p.F657L	DO234359	ESAD	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.3056
p.Y743C	DO233214	GACA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.1667
p.S764R	DO229026	LICA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.1389
p.E643G	DO232849	NACA	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.1111
p.V655G	DO218012	ORCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation altering degron motif	0.7532
p.V745L	DO232624	PBCA	ICGC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.2222
p.S659F	DO229221	THCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.25
p.F646L	DO229242	THCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.1944
p.D740N	SIDM00582	Pancreatic Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0833
p.D740N	KP-2	pancreas	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0833
p.E641Q	SIDM00864	Cervical Carcinoma	GDSC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.0556
p.E641Q	DoTc2-4510	cervix	COSMIC	LCPHGE	LIG_APCC_ABBA_1	651:656	Mutation rewiring degron network	0.0556
p.V757F	SIDM01779	Gastric Carcinoma	GDSC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.7068
p.R766W	ACH-000181	Head and Neck Cancer	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0833
p.R766W	ACH-000432	Leukemia	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0833
p.R766W	BV-173	haematopoietic and lymphoid tissue	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0833
p.R766W	SCC-9	upper aerodigestive tract	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.0833
p.D752N	ACH-000281	Pancreatic Cancer	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.6932
p.D752N	KP-2	pancreas	COSMIC	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation altering degron motif	0.6932
p.P742L	ACH-001369	Ovarian Cancer	CCLE	FVEEWRKFV	DEG_MDM2_SWIB_1	749:757	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP48

UniProt ID: Q86UV5

Entrez ID: 84196

Protein name: Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP48 in