DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LCPHGE
Uniprot ID:
Q86UV5
Source protein:
Ubiquitin carboxyl-terminal hydrolase 48
Source gene:
USP48
Class:
LIG_APCC_ABBA_1
Location:
651:656
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5148
ASA_SCORE:
63.05
COIL:
0.7197
CONS_SCORE:
0.4459
DSS_SCORE:
0.3063
HELIX:
0.0623
FCONS_SCORE:
1.1207
RIG_SCORE:
0.7954
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L651M
TCGA-B5-A11E
UCEC
TCGA
LCPHGE
LIG_APCC_ABBA_1
0.5999
p.L651M
DO41644
UCEC
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.5999
p.L657V
TCGA-EO-A3B0
UCEC
TCGA
LCPHGE
LIG_APCC_ABBA_1
0.3056
p.L657V
DO219773
UCEC
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.3056
p.P653S
TCGA-S5-A6DX
BLCA
TCGA
LCPHGE
LIG_APCC_ABBA_1
0.6752
p.P653S
DO51903
BLCA
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.6752
p.P653S
DO51509
PACA
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.6752
p.N645K
TCGA-UZ-A9PS
KIRP
TCGA
LCPHGE
LIG_APCC_ABBA_1
0.1667
p.N645K
DO219709
KIRP
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.1667
p.F657L
DO234359
ESAD
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.3056
p.E643G
DO232849
NACA
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.1111
p.V655G
DO218012
ORCA
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.7532
p.S659F
DO229221
THCA
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.25
p.F646L
DO229242
THCA
ICGC
LCPHGE
LIG_APCC_ABBA_1
0.1944
p.E641Q
SIDM00864
Cervical Carcinoma
GDSC
LCPHGE
LIG_APCC_ABBA_1
0.0556
p.E641Q
DoTc2-4510
cervix
COSMIC
LCPHGE
LIG_APCC_ABBA_1
0.0556
Drug responses associated with USP48 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LCPHGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86UV5
Ubiquitin carboxyl-terminal hydrolase 48
LIG_APCC_ABBA_1
651:656
LCPHGE
APC,CDC20,FZR1
0.5148
More...