DegronMD

Uniprot ID: Q86UV5

Source protein: Ubiquitin carboxyl-terminal hydrolase 48

Source gene: USP48

Class: LIG_APCC_ABBA_1

Location: 651:656

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5148

ASA_SCORE: 63.05

COIL: 0.7197

CONS_SCORE: 0.4459

DSS_SCORE: 0.3063

HELIX: 0.0623

FCONS_SCORE: 1.1207

RIG_SCORE: 0.7954

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V655G	DO218012	ORCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.7532
p.P653S	TCGA-S5-A6DX	BLCA	TCGA	LCPHGE	LIG_APCC_ABBA_1	0.6752
p.P653S	DO51903	BLCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.6752
p.P653S	DO51509	PACA	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.6752
p.L651M	TCGA-B5-A11E	UCEC	TCGA	LCPHGE	LIG_APCC_ABBA_1	0.5999
p.L651M	DO41644	UCEC	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.5999
p.L657V	TCGA-EO-A3B0	UCEC	TCGA	LCPHGE	LIG_APCC_ABBA_1	0.3056
p.L657V	DO219773	UCEC	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.3056
p.F657L	DO234359	ESAD	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.3056
p.S659F	DO229221	THCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.25
p.F646L	DO229242	THCA	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.1944
p.N645K	TCGA-UZ-A9PS	KIRP	TCGA	LCPHGE	LIG_APCC_ABBA_1	0.1667
p.N645K	DO219709	KIRP	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.1667
p.E643G	DO232849	NACA	ICGC	LCPHGE	LIG_APCC_ABBA_1	0.1111
p.E641Q	SIDM00864	Cervical Carcinoma	GDSC	LCPHGE	LIG_APCC_ABBA_1	0.0556
p.E641Q	DoTc2-4510	cervix	COSMIC	LCPHGE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UV5	Ubiquitin carboxyl-terminal hydrolase 48	LIG_APCC_ABBA_1	651:656	LCPHGE	APC,CDC20,FZR1	0.5148	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons