DegronMD

Uniprot ID: Q8TB96

Source protein: T-cell immunomodulatory protein

Source gene: ITFG1

Class: LIG_APCC_ABBA_1

Location: 316:321

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6443

ASA_SCORE: 53.25

COIL: 0.6423

CONS_SCORE: 0.3888

DSS_SCORE: 0.2805

HELIX: 0.0418

FCONS_SCORE: 1.1284

RIG_SCORE: 0.8967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P318L	TCGA-D6-6516	HNSC	TCGA	FVPFVD	LIG_APCC_ABBA_1	0.6471
p.P318L	DO15623	HNSC	ICGC	FVPFVD	LIG_APCC_ABBA_1	0.6471
p.P329Q	DO233160	GACA	ICGC	FVPFVD	LIG_APCC_ABBA_1	0.1111
p.P318S	DO228138	PBCA	ICGC	FVPFVD	LIG_APCC_ABBA_1	0.6752
p.K310R	SIDM00660	Colorectal Carcinoma	GDSC	FVPFVD	LIG_APCC_ABBA_1	0.2778
p.V320A	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	FVPFVD	LIG_APCC_ABBA_1	0.5825
p.T312S	SIDM00730	Small Cell Lung Carcinoma	GDSC	FVPFVD	LIG_APCC_ABBA_1	0.2222
p.T312S	ACH-000610	Lung Cancer	CCLE	FVPFVD	LIG_APCC_ABBA_1	0.2222
p.T312S	NCI-H2227	lung	COSMIC	FVPFVD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TB96	T-cell immunomodulatory protein	LIG_APCC_ABBA_1	316:321	FVPFVD	APC,CDC20,FZR1	0.6443	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons