DegronMD

Uniprot ID: P23515

Source protein: Oligodendrocyte-myelin glycoprotein

Source gene: OMG

Class: LIG_APCC_ABBA_1

Location: 331:336

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9179

ASA_SCORE: 72.4833

COIL: 0.665

CONS_SCORE: 0.6138

DSS_SCORE: 0.4968

HELIX: 0.0527

FCONS_SCORE: 1.1384

RIG_SCORE: 0.7701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D321Y	TCGA-AX-A2HD	UCEC	TCGA	FVPYPE	LIG_APCC_ABBA_1	0.0556
p.D321Y	TCGA-B5-A0JY	UCEC	TCGA	FVPYPE	LIG_APCC_ABBA_1	0.0556
p.D321Y	DO43041	UCEC	ICGC	FVPYPE	LIG_APCC_ABBA_1	0.0556
p.D321Y	DO42608	UCEC	ICGC	FVPYPE	LIG_APCC_ABBA_1	0.0556
p.S345T	TCGA-BC-A5W4	LIHC	TCGA	FVPYPE	LIG_APCC_ABBA_1	0.0833
p.S345T	DO44962	LIHC	ICGC	FVPYPE	LIG_APCC_ABBA_1	0.0833
p.A330T	TCGA-EB-A3Y7	SKCM	TCGA	FVPYPE	LIG_APCC_ABBA_1	0.3056
p.A330T	DO37499	SKCM	ICGC	FVPYPE	LIG_APCC_ABBA_1	0.3056
p.T323N	DO229045	LICA	ICGC	FVPYPE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23515	Oligodendrocyte-myelin glycoprotein	LIG_APCC_ABBA_1	331:336	FVPYPE	APC,CDC20,FZR1	0.9179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons