DegronMD - P23515(OMG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E244A	TCGA-06-1802	GBM	TCGA	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation rewiring degron network	0.1944
p.E244A	DO12100	GBM	ICGC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation rewiring degron network	0.1944
p.P253L	TCGA-61-2009	OV	TCGA	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation altering degron motif	0.7582
p.P253L	DO28992	OV	ICGC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation altering degron motif	0.7582
p.A426T	TCGA-A5-A0GP	UCEC	TCGA	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.0833
p.A426T	DO41109	UCEC	ICGC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.0833
p.K412N	TCGA-AA-3984	COAD	TCGA	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation altering degron motif	0.5806
p.K412N	DO9002	COAD	ICGC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation altering degron motif	0.5806
p.K262Q	TCGA-AJ-A5DW	UCEC	TCGA	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation substituting flanking lysine	0.2778
p.K262Q	DO50075	UCEC	ICGC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation substituting flanking lysine	0.2778
p.S417Y	TCGA-AX-A2HC	UCEC	TCGA	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation altering degron motif	0.712
p.S417Y	DO41572	UCEC	ICGC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation altering degron motif	0.712
p.D321Y	TCGA-AX-A2HD	UCEC	TCGA	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0556
p.D321Y	TCGA-B5-A0JY	UCEC	TCGA	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0556
p.D321Y	DO43041	UCEC	ICGC	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0556
p.D321Y	DO42608	UCEC	ICGC	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0556
p.S345T	TCGA-BC-A5W4	LIHC	TCGA	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0833
p.S345T	DO44962	LIHC	ICGC	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0833
p.A330T	TCGA-EB-A3Y7	SKCM	TCGA	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.A330T	DO37499	SKCM	ICGC	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.N401H	DO234156	ESAD	ICGC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.0556
p.T409K	DO229019	LICA	ICGC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.2778
p.A419E	DO229031	LICA	ICGC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.2778
p.T323N	DO229045	LICA	ICGC	FVPYPE	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1111
p.N265S	DO50846	LICA	ICGC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation rewiring degron network	0.0833
p.A247V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation rewiring degron network	0.2778
p.A247V	ACH-000665	Lung Cancer	CCLE	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation rewiring degron network	0.2778
p.A247V	SK-MES-1	lung	COSMIC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation rewiring degron network	0.2778
p.G251W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation altering degron motif	0.6714
p.G251W	ACH-000920	Leukemia	CCLE	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation altering degron motif	0.6714
p.G251W	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VIGTPCST	DEG_SCF_FBW7_1	249:256	Mutation altering degron motif	0.6714
p.W422L	SIDM00628	Breast Carcinoma	GDSC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.1944
p.W422L	ACH-000849	Breast Cancer	CCLE	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.1944
p.W422L	MDA-MB-468	breast	COSMIC	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.1944
p.A421V	ACH-001379	Pancreatic Cancer	CCLE	VKTPLPS	DEG_SCF_FBW7_1	411:417	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OMG

UniProt ID: P23515

Entrez ID: 4974

Protein name: Oligodendrocyte-myelin glycoprotein

External links: UniprotKB HGNC RefSeq COSMIC

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