DegronMD

Uniprot ID: P23515

Source protein: Oligodendrocyte-myelin glycoprotein

Source gene: OMG

Class: DEG_SCF_FBW7_1

Location: 249:256

E3 ligase: FBXW7

DEGRON score: 0.7496

ASA_SCORE: 50.5875

COIL: 0.7071

CONS_SCORE: 0.5794

DSS_SCORE: 0.2843

HELIX: 0.2216

FCONS_SCORE: 1.0527

RIG_SCORE: 0.7759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E244A	TCGA-06-1802	GBM	TCGA	VIGTPCST	DEG_SCF_FBW7_1	0.1944
p.E244A	DO12100	GBM	ICGC	VIGTPCST	DEG_SCF_FBW7_1	0.1944
p.P253L	TCGA-61-2009	OV	TCGA	VIGTPCST	DEG_SCF_FBW7_1	0.7582
p.P253L	DO28992	OV	ICGC	VIGTPCST	DEG_SCF_FBW7_1	0.7582
p.K262Q	TCGA-AJ-A5DW	UCEC	TCGA	VIGTPCST	DEG_SCF_FBW7_1	0.2778
p.K262Q	DO50075	UCEC	ICGC	VIGTPCST	DEG_SCF_FBW7_1	0.2778
p.N265S	DO50846	LICA	ICGC	VIGTPCST	DEG_SCF_FBW7_1	0.0833
p.A247V	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	VIGTPCST	DEG_SCF_FBW7_1	0.2778
p.A247V	ACH-000665	Lung Cancer	CCLE	VIGTPCST	DEG_SCF_FBW7_1	0.2778
p.A247V	SK-MES-1	lung	COSMIC	VIGTPCST	DEG_SCF_FBW7_1	0.2778
p.G251W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VIGTPCST	DEG_SCF_FBW7_1	0.6714
p.G251W	ACH-000920	Leukemia	CCLE	VIGTPCST	DEG_SCF_FBW7_1	0.6714
p.G251W	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VIGTPCST	DEG_SCF_FBW7_1	0.6714

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23515	Oligodendrocyte-myelin glycoprotein	DEG_SCF_FBW7_1	249:256	VIGTPCST	FBXW7	0.7496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons