DegronMD

Uniprot ID: P23515

Source protein: Oligodendrocyte-myelin glycoprotein

Source gene: OMG

Class: DEG_SCF_FBW7_1

Location: 411:417

E3 ligase: FBXW7

DEGRON score: 0.6619

ASA_SCORE: 73.5714

COIL: 0.8693

CONS_SCORE: 0.5622

DSS_SCORE: 0.3172

HELIX: 0.027

FCONS_SCORE: 1.081

RIG_SCORE: 0.8144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A426T	TCGA-A5-A0GP	UCEC	TCGA	VKTPLPS	DEG_SCF_FBW7_1	0.0833
p.A426T	DO41109	UCEC	ICGC	VKTPLPS	DEG_SCF_FBW7_1	0.0833
p.K412N	TCGA-AA-3984	COAD	TCGA	VKTPLPS	DEG_SCF_FBW7_1	0.5806
p.K412N	DO9002	COAD	ICGC	VKTPLPS	DEG_SCF_FBW7_1	0.5806
p.S417Y	TCGA-AX-A2HC	UCEC	TCGA	VKTPLPS	DEG_SCF_FBW7_1	0.712
p.S417Y	DO41572	UCEC	ICGC	VKTPLPS	DEG_SCF_FBW7_1	0.712
p.N401H	DO234156	ESAD	ICGC	VKTPLPS	DEG_SCF_FBW7_1	0.0556
p.T409K	DO229019	LICA	ICGC	VKTPLPS	DEG_SCF_FBW7_1	0.2778
p.A419E	DO229031	LICA	ICGC	VKTPLPS	DEG_SCF_FBW7_1	0.2778
p.W422L	SIDM00628	Breast Carcinoma	GDSC	VKTPLPS	DEG_SCF_FBW7_1	0.1944
p.W422L	ACH-000849	Breast Cancer	CCLE	VKTPLPS	DEG_SCF_FBW7_1	0.1944
p.W422L	MDA-MB-468	breast	COSMIC	VKTPLPS	DEG_SCF_FBW7_1	0.1944
p.A421V	ACH-001379	Pancreatic Cancer	CCLE	VKTPLPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23515	Oligodendrocyte-myelin glycoprotein	DEG_SCF_FBW7_1	411:417	VKTPLPS	FBXW7	0.6619	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons