DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
GGEGTPVK
Uniprot ID:
Q9Y4B5
Source protein:
Microtubule cross-linking factor 1
Source gene:
MTCL1
Class:
DEG_SCF_SKP2-CKS1_1
Location:
1827:1834
E3 ligase:
SKP2,CSK1
DEGRON score:
0.9799
ASA_SCORE:
78.525
COIL:
0.7958
CONS_SCORE:
0.429
DSS_SCORE:
0.6588
HELIX:
0.0213
FCONS_SCORE:
0.9065
RIG_SCORE:
0.6279
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1832S
VMRC-LCD
lung
COSMIC
GGEGTPVK
DEG_SCF_SKP2-CKS1_1
0.6752
p.Q1835R
MFE-319
endometrium
COSMIC
GGEGTPVK
DEG_SCF_SKP2-CKS1_1
0.3056
p.M1822V
HT-1376
urinary_tract
COSMIC
GGEGTPVK
DEG_SCF_SKP2-CKS1_1
0.1944
Drug responses associated with MTCL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GGEGTPVK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4B5
Microtubule cross-linking factor 1
DEG_SCF_SKP2-CKS1_1
1827:1834
GGEGTPVK
SKP2,CSK1
0.9799
More...