DegronMD

Uniprot ID: O75969

Source protein: A-kinase anchor protein 3

Source gene: AKAP3

Class: DEG_SCF_SKP2-CKS1_1

Location: 162:169

E3 ligase: SKP2,CSK1

DEGRON score: 0.8594

ASA_SCORE: 86.375

COIL: 0.8255

CONS_SCORE: 0.8397

DSS_SCORE: 0.3754

HELIX: 0.1386

FCONS_SCORE: 0.9263

RIG_SCORE: 0.7019

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T168P	TCGA-06-5416	GBM	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.5919
p.T168P	DO10880	GBM	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.5919
p.K169T	TCGA-AG-A002	READ	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.7306
p.L159S	TCGA-BS-A0UJ	UCEC	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.L159S	DO42745	UCEC	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.K153N	TCGA-EE-A3J5	SKCM	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.K153N	DO47331	SKCM	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.N152K	TCGA-GN-A269	SKCM	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.0556
p.N152K	DO37483	SKCM	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E164V	DO34656	PACA	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.7693
p.Q157R	SIDM00215	Colorectal Carcinoma	GDSC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.Q157R	ACH-000708	Colon/Colorectal Cancer	CCLE	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.Q157R	SNU-283	large_intestine	COSMIC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.L178P	SIDM00889	Cervical Carcinoma	GDSC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L178P	ACH-001333	Cervical Cancer	CCLE	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L178P	C-33-A	cervix	COSMIC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.I174L	ACH-000793	Gastric Cancer	CCLE	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75969	A-kinase anchor protein 3	DEG_SCF_SKP2-CKS1_1	162:169	GNEPTPTK	SKP2,CSK1	0.8594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons