DegronMD - O75969(AKAP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y435N	TCGA-05-5425	LUAD	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.7059
p.Y435N	DO26270	LUAD	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.7059
p.T168P	TCGA-06-5416	GBM	TCGA	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation altering degron motif	0.5919
p.T168P	TCGA-06-5416	GBM	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation altering degron motif	0.5919
p.T168P	DO10880	GBM	ICGC	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation altering degron motif	0.5919
p.T168P	DO10880	GBM	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation altering degron motif	0.5919
p.A446V	TCGA-A5-A0VP	UCEC	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation rewiring degron network	0.0833
p.A446V	DO42600	UCEC	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation rewiring degron network	0.0833
p.A446V	ACH-001991	Primary	CCLE	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation rewiring degron network	0.0833
p.K169T	TCGA-AG-A002	READ	TCGA	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation altering degron motif	0.6195
p.K169T	TCGA-AG-A002	READ	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation altering degron motif	0.7306
p.L159S	TCGA-BS-A0UJ	UCEC	TCGA	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1667
p.L159S	TCGA-BS-A0UJ	UCEC	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.25
p.L159S	DO42745	UCEC	ICGC	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1667
p.L159S	DO42745	UCEC	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.25
p.R431T	TCGA-CV-6961	HNSC	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.7876
p.R431T	DO14566	HNSC	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.7876
p.E437K	TCGA-D8-A27G	BRCA	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.7022
p.E437K	DO5465	BRCA	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.7022
p.K153N	TCGA-EE-A3J5	SKCM	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation substituting flanking lysine	0.1944
p.K153N	DO47331	SKCM	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation substituting flanking lysine	0.1944
p.K425T	TCGA-EO-A3B0	UCEC	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation substituting flanking lysine	0.2778
p.K425T	DO219773	UCEC	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation substituting flanking lysine	0.2778
p.N152K	TCGA-GN-A269	SKCM	TCGA	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.0556
p.N152K	DO37483	SKCM	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.0556
p.M434I	DO7214	CLLE	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.6507
p.E437G	DO233291	GACA	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation altering degron motif	0.7199
p.C445S	DO46378	OV	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation rewiring degron network	0.1111
p.E164V	DO34656	PACA	ICGC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation altering degron motif	0.7693
p.K439Q	DO46765	PAEN	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation rewiring degron network	0.2778
p.Q157R	SIDM00215	Colorectal Carcinoma	GDSC	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1111
p.Q157R	SIDM00215	Colorectal Carcinoma	GDSC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.1944
p.Q157R	ACH-000708	Colon/Colorectal Cancer	CCLE	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1111
p.Q157R	ACH-000708	Colon/Colorectal Cancer	CCLE	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.1944
p.Q157R	SNU-283	large intestine	COSMIC	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1111
p.Q157R	SNU-283	large intestine	COSMIC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.1944
p.L178P	SIDM00889	Cervical Carcinoma	GDSC	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1111
p.L178P	SIDM00889	Cervical Carcinoma	GDSC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.0833
p.L178P	ACH-001333	Cervical Cancer	CCLE	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1111
p.L178P	ACH-001333	Cervical Cancer	CCLE	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.0833
p.L178P	C-33-A	cervix	COSMIC	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.1111
p.L178P	C-33-A	cervix	COSMIC	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.0833
p.I174L	ACH-000793	Gastric Cancer	CCLE	PTPTKS	DEG_SCF_FBW7_1	165:170	Mutation rewiring degron network	0.2222
p.I174L	ACH-000793	Gastric Cancer	CCLE	GNEPTPTK	DEG_SCF_SKP2-CKS1_1	162:169	Mutation rewiring degron network	0.1944
p.P438S	ACH-001523	Skin Cancer	CCLE	REKMYSE	LIG_APCC_ABBAyCdc20_2	431:437	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP3

UniProt ID: O75969

Entrez ID: 10566

Protein name: A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP3 in