DegronMD

Uniprot ID: O75969

Source protein: A-kinase anchor protein 3

Source gene: AKAP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 431:437

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7139

ASA_SCORE: 115.2143

COIL: 0.5511

CONS_SCORE: 0.5882

DSS_SCORE: 0.534

HELIX: 0.2726

FCONS_SCORE: 0.7503

RIG_SCORE: 0.724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y435N	TCGA-05-5425	LUAD	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.7059
p.Y435N	DO26270	LUAD	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.7059
p.A446V	TCGA-A5-A0VP	UCEC	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A446V	DO42600	UCEC	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A446V	ACH-001991	Primary	CCLE	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R431T	TCGA-CV-6961	HNSC	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.7876
p.R431T	DO14566	HNSC	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.7876
p.E437K	TCGA-D8-A27G	BRCA	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E437K	DO5465	BRCA	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.K425T	TCGA-EO-A3B0	UCEC	TCGA	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K425T	DO219773	UCEC	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M434I	DO7214	CLLE	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.6507
p.E437G	DO233291	GACA	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.7199
p.C445S	DO46378	OV	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.K439Q	DO46765	PAEN	ICGC	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P438S	ACH-001523	Skin Cancer	CCLE	REKMYSE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75969	A-kinase anchor protein 3	LIG_APCC_ABBAyCdc20_2	431:437	REKMYSE	APC,CDC20,FZR1	0.7139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons