DegronMD

Uniprot ID: O75969

Source protein: A-kinase anchor protein 3

Source gene: AKAP3

Class: DEG_SCF_FBW7_1

Location: 165:170

E3 ligase: FBXW7

DEGRON score: 0.5974

ASA_SCORE: 77.1833

COIL: 0.6812

CONS_SCORE: 0.8482

DSS_SCORE: 0.4049

HELIX: 0.2893

FCONS_SCORE: 0.9351

RIG_SCORE: 0.7187

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T168P	TCGA-06-5416	GBM	TCGA	PTPTKS	DEG_SCF_FBW7_1	0.5919
p.T168P	DO10880	GBM	ICGC	PTPTKS	DEG_SCF_FBW7_1	0.5919
p.K169T	TCGA-AG-A002	READ	TCGA	PTPTKS	DEG_SCF_FBW7_1	0.6195
p.L159S	TCGA-BS-A0UJ	UCEC	TCGA	PTPTKS	DEG_SCF_FBW7_1	0.1667
p.L159S	DO42745	UCEC	ICGC	PTPTKS	DEG_SCF_FBW7_1	0.1667
p.Q157R	SIDM00215	Colorectal Carcinoma	GDSC	PTPTKS	DEG_SCF_FBW7_1	0.1111
p.Q157R	ACH-000708	Colon/Colorectal Cancer	CCLE	PTPTKS	DEG_SCF_FBW7_1	0.1111
p.Q157R	SNU-283	large_intestine	COSMIC	PTPTKS	DEG_SCF_FBW7_1	0.1111
p.L178P	SIDM00889	Cervical Carcinoma	GDSC	PTPTKS	DEG_SCF_FBW7_1	0.1111
p.L178P	ACH-001333	Cervical Cancer	CCLE	PTPTKS	DEG_SCF_FBW7_1	0.1111
p.L178P	C-33-A	cervix	COSMIC	PTPTKS	DEG_SCF_FBW7_1	0.1111
p.I174L	ACH-000793	Gastric Cancer	CCLE	PTPTKS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75969	A-kinase anchor protein 3	DEG_SCF_FBW7_1	165:170	PTPTKS	FBXW7	0.5974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons