DegronMD

Uniprot ID: Q02833

Source protein: Ras association domain-containing protein 7

Source gene: RASSF7

Class: DEG_SIAH_1

Location: 140:148

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9992

ASA_SCORE: 78.3222

COIL: 0.937

CONS_SCORE: 0.4988

DSS_SCORE: 0.6192

HELIX: 0.0159

FCONS_SCORE: 1.3788

RIG_SCORE: 0.5968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R138C	DO222973	BTCA	ICGC	GPAAPVTPT	DEG_SIAH_1	0.2778
p.R138C	SIDM00899	Pancreatic Carcinoma	GDSC	GPAAPVTPT	DEG_SIAH_1	0.2778
p.R138C	SIDM01475	Ovarian Carcinoma	GDSC	GPAAPVTPT	DEG_SIAH_1	0.2778
p.R138H	DO222765	COCA	ICGC	GPAAPVTPT	DEG_SIAH_1	0.2778
p.R156Q	DO229013	COCA	ICGC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.R156Q	DO229016	COCA	ICGC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.R156Q	DO229473	LAML	ICGC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.R156Q	DO229489	LAML	ICGC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.R156Q	DO231104	LUSC	ICGC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.R156Q	DO231102	LUSC	ICGC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.A143V	DO33091	PACA	ICGC	GPAAPVTPT	DEG_SIAH_1	0.6936
p.A143V	SIDM01617	Endometrial Carcinoma	GDSC	GPAAPVTPT	DEG_SIAH_1	0.6936
p.A143V	ACH-000994	Endometrial/Uterine Cancer	CCLE	GPAAPVTPT	DEG_SIAH_1	0.6936
p.P149L	DO229272	THCA	ICGC	GPAAPVTPT	DEG_SIAH_1	0.3056
p.P130L	DO229245	THCA	ICGC	GPAAPVTPT	DEG_SIAH_1	0.0556
p.A133V	SIDM00085	Glioma	GDSC	GPAAPVTPT	DEG_SIAH_1	0.1389
p.A133V	ACH-000655	Brain Cancer	CCLE	GPAAPVTPT	DEG_SIAH_1	0.1389
p.R156P	SIDM01653	Non-Cancerous	GDSC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.R156P	SIDM00207	Glioblastoma	GDSC	GPAAPVTPT	DEG_SIAH_1	0.1111
p.R156P	SIDM00380	Acute Myeloid Leukemia	GDSC	GPAAPVTPT	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02833	Ras association domain-containing protein 7	DEG_SIAH_1	140:148	GPAAPVTPT	SIAH1,SIAH2,SIAH3	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons