DegronMD

Uniprot ID: Q8IVW6

Source protein: AT-rich interactive domain-containing protein 3B

Source gene: ARID3B

Class: DEG_SIAH_1

Location: 67:75

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9031

ASA_SCORE: 84.9556

COIL: 0.8251

CONS_SCORE: 0.2691

DSS_SCORE: 0.5856

HELIX: 0.161

FCONS_SCORE: 0.8925

RIG_SCORE: 0.6836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G85V	TCGA-68-A59J	LUSC	TCGA	GPLARVPPT	DEG_SIAH_1	0.0556
p.G85V	DO49085	LUSC	ICGC	GPLARVPPT	DEG_SIAH_1	0.0556
p.P65H	TCGA-80-5608	LUAD	TCGA	GPLARVPPT	DEG_SIAH_1	0.2778
p.P65H	DO23693	LUAD	ICGC	GPLARVPPT	DEG_SIAH_1	0.2778
p.E83Q	TCGA-E7-A7XN	BLCA	TCGA	GPLARVPPT	DEG_SIAH_1	0.1111
p.E83Q	DO51878	BLCA	ICGC	GPLARVPPT	DEG_SIAH_1	0.1111
p.E83Q	DO220823	BRCA	ICGC	GPLARVPPT	DEG_SIAH_1	0.1111
p.P68S	TCGA-ER-A19G	SKCM	TCGA	GPLARVPPT	DEG_SIAH_1	0.6752
p.P68S	DO47284	SKCM	ICGC	GPLARVPPT	DEG_SIAH_1	0.6752
p.R71S	TCGA-EY-A215	UCEC	TCGA	GPLARVPPT	DEG_SIAH_1	0.6316
p.R71S	DO42665	UCEC	ICGC	GPLARVPPT	DEG_SIAH_1	0.6316
p.G67C	DO229015	LICA	ICGC	GPLARVPPT	DEG_SIAH_1	0.6489
p.A76T	DO228138	PBCA	ICGC	GPLARVPPT	DEG_SIAH_1	0.3056
p.A77T	SIDM00534	Colorectal Carcinoma	GDSC	GPLARVPPT	DEG_SIAH_1	0.2778
p.A77T	ACH-000986	Colon/Colorectal Cancer	CCLE	GPLARVPPT	DEG_SIAH_1	0.2778
p.A77T	HT-115	large_intestine	COSMIC	GPLARVPPT	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVW6	AT-rich interactive domain-containing protein 3B	DEG_SIAH_1	67:75	GPLARVPPT	SIAH1,SIAH2,SIAH3	0.9031	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons