DegronMD

Uniprot ID: Q86WN1

Source protein: F-BAR and double SH3 domains protein 1

Source gene: FCHSD1

Class: DEG_SIAH_1

Location: 642:650

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.999

ASA_SCORE: 74.6333

COIL: 0.966

CONS_SCORE: 0.384

DSS_SCORE: 0.6096

HELIX: 0.0166

FCONS_SCORE: 1.1061

RIG_SCORE: 0.6206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A645T	TCGA-06-5416	GBM	TCGA	GPPAPVLPG	DEG_SIAH_1	0.7139
p.D655Y	TCGA-A5-A0G1	UCEC	TCGA	GPPAPVLPG	DEG_SIAH_1	0.1944
p.D655Y	DO42472	UCEC	ICGC	GPPAPVLPG	DEG_SIAH_1	0.1944
p.L660M	TCGA-BR-4361	STAD	TCGA	GPPAPVLPG	DEG_SIAH_1	0.0556
p.L660M	DO38887	STAD	ICGC	GPPAPVLPG	DEG_SIAH_1	0.0556
p.P649A	ACH-000198	Leukemia	CCLE	GPPAPVLPG	DEG_SIAH_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WN1	F-BAR and double SH3 domains protein 1	DEG_SIAH_1	642:650	GPPAPVLPG	SIAH1,SIAH2,SIAH3	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons