DegronMD - Q86WN1(FCHSD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A645T	TCGA-06-5416	GBM	TCGA	GPPAPVLPG	DEG_SIAH_1	642:650	Mutation altering degron motif	0.7139
p.D655Y	TCGA-A5-A0G1	UCEC	TCGA	GPPAPVLPG	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.D655Y	DO42472	UCEC	ICGC	GPPAPVLPG	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.1944
p.R174Q	TCGA-AX-A2HC	UCEC	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1111
p.R174Q	TCGA-DK-A6AW	BLCA	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1111
p.R174Q	TCGA-EO-A3AV	UCEC	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1111
p.L660M	TCGA-BR-4361	STAD	TCGA	GPPAPVLPG	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0556
p.L660M	DO38887	STAD	ICGC	GPPAPVLPG	DEG_SIAH_1	642:650	Mutation rewiring degron network	0.0556
p.A195T	TCGA-EO-A3B0	UCEC	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1944
p.R172Q	DO48566	BLCA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.0556
p.R172Q	DO52412	UCEC	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.0556
p.R172Q	DO41572	UCEC	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.0556
p.A196S	DO224768	BRCA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1667
p.R181W	DO233115	GACA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.3056
p.T182N	DO229045	LICA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.7055
p.H175N	DO229009	LICA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.1389
p.A193T	DO219773	UCEC	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation rewiring degron network	0.25
p.R183W	SIDM00122	Breast Carcinoma	GDSC	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.8634
p.P649A	ACH-000198	Leukemia	CCLE	GPPAPVLPG	DEG_SIAH_1	642:650	Mutation altering degron motif	0.7503
p.A184T	ACH-000977	lymph node	CCLE	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.7139
p.V186I	ACH-001623	Brain Cancer	CCLE	SRTSLQKLS	DEG_APCC_DBOX_1	182:190	Mutation altering degron motif	0.7076

Kaplan plot for FCHSD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCHSD1

UniProt ID: Q86WN1

Entrez ID: 89848

Protein name: F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FCHSD1 in