DegronMD

Uniprot ID: Q86WN1

Source protein: F-BAR and double SH3 domains protein 1

Source gene: FCHSD1

Class: DEG_APCC_DBOX_1

Location: 182:190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6101

ASA_SCORE: 87.7222

COIL: 0.3508

CONS_SCORE: 0.4652

DSS_SCORE: 0.3825

HELIX: 0.632

FCONS_SCORE: 1.128

RIG_SCORE: 0.7263

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R174Q	TCGA-AX-A2HC	UCEC	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	0.1111
p.R174Q	TCGA-DK-A6AW	BLCA	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	0.1111
p.R174Q	TCGA-EO-A3AV	UCEC	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	0.1111
p.A195T	TCGA-EO-A3B0	UCEC	TCGA	SRTSLQKLS	DEG_APCC_DBOX_1	0.1944
p.R172Q	DO48566	BLCA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.0556
p.R172Q	DO52412	UCEC	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.0556
p.R172Q	DO41572	UCEC	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.0556
p.A196S	DO224768	BRCA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.1667
p.R181W	DO233115	GACA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.3056
p.T182N	DO229045	LICA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.7055
p.H175N	DO229009	LICA	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.1389
p.A193T	DO219773	UCEC	ICGC	SRTSLQKLS	DEG_APCC_DBOX_1	0.25
p.R183W	SIDM00122	Breast Carcinoma	GDSC	SRTSLQKLS	DEG_APCC_DBOX_1	0.8634
p.A184T	ACH-000977	lymph_node	CCLE	SRTSLQKLS	DEG_APCC_DBOX_1	0.7139
p.V186I	ACH-001623	Brain Cancer	CCLE	SRTSLQKLS	DEG_APCC_DBOX_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WN1	F-BAR and double SH3 domains protein 1	DEG_APCC_DBOX_1	182:190	SRTSLQKLS	APC,CDC20,FZR1	0.6101	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons