DegronMD

Uniprot ID: Q14244

Source protein: Ensconsin

Source gene: MAP7

Class: DEG_APCC_DBOX_1

Location: 400:408

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9726

ASA_SCORE: 101.8667

COIL: 0.8976

CONS_SCORE: 0.466

DSS_SCORE: 0.5921

HELIX: 0.0549

FCONS_SCORE: 1.3213

RIG_SCORE: 0.7025

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K395N	TCGA-17-Z033	LUAD	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.1944
p.R392H	TCGA-AA-A022	COAD	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.1111
p.R392H	DO10647	COAD	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.1111
p.K413T	TCGA-AG-A002	READ	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.1944
p.Q412H	TCGA-AX-A2IO	UCEC	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.2222
p.Q412H	DO40800	UCEC	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.2222
p.E410K	TCGA-D3-A8GI	SKCM	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.2778
p.E410K	TCGA-W3-AA1V	SKCM	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.2778
p.E410K	DO50284	SKCM	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.2778
p.E410K	DO51276	SKCM	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.2778
p.E403Q	TCGA-D8-A1J8	BRCA	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.6744
p.E403Q	DO1269	BRCA	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.6744
p.K399N	TCGA-D9-A6EC	SKCM	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.3056
p.E397K	TCGA-ER-A193	SKCM	TCGA	GRAPLVKVE	DEG_APCC_DBOX_1	0.6944
p.E397K	DO47368	SKCM	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.6944
p.K409N	DO233258	GACA	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.3056
p.R392C	DO222363	MELA	ICGC	GRAPLVKVE	DEG_APCC_DBOX_1	0.1111
p.Q390P	SIDM00850	Gastric Carcinoma	GDSC	GRAPLVKVE	DEG_APCC_DBOX_1	0.0556
p.Q390P	AGS	stomach	COSMIC	GRAPLVKVE	DEG_APCC_DBOX_1	0.0556
p.A418T	ACH-000328	Brain Cancer	CCLE	GRAPLVKVE	DEG_APCC_DBOX_1	0.0556
p.R415W	ACH-000988	Endometrial/Uterine Cancer	CCLE	GRAPLVKVE	DEG_APCC_DBOX_1	0.1389
p.R415W	MFE-319	endometrium	COSMIC	GRAPLVKVE	DEG_APCC_DBOX_1	0.1389
p.T416I	ACH-001737	Leukemia	CCLE	GRAPLVKVE	DEG_APCC_DBOX_1	0.1111
p.T416I	ACH-002222	Leukemia	CCLE	GRAPLVKVE	DEG_APCC_DBOX_1	0.1111
p.T416I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRAPLVKVE	DEG_APCC_DBOX_1	0.1111
p.R400W	MFE-319	endometrium	COSMIC	GRAPLVKVE	DEG_APCC_DBOX_1	0.8634
p.E398K	PANC-08-13	pancreas	COSMIC	GRAPLVKVE	DEG_APCC_DBOX_1	0.2778
p.T401I	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRAPLVKVE	DEG_APCC_DBOX_1	0.7078
p.L413P	TE-4	oesophagus	COSMIC	GRAPLVKVE	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRAPLVKVE

Degron related mutations and impact score

Drug responses associated with MAP7 mutations

All proteins holding degron of GRAPLVKVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14244	Ensconsin	DEG_APCC_DBOX_1	400:408	GRAPLVKVE	APC,CDC20,FZR1	0.9726	More...