DegronMD

Uniprot ID: Q14807

Source protein: Kinesin-like protein KIF22

Source gene: KIF22

Class: DEG_APCC_DBOX_1

Location: 26:34

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.893

ASA_SCORE: 101.4667

COIL: 0.8118

CONS_SCORE: 0.2891

DSS_SCORE: 0.4618

HELIX: 0.1783

FCONS_SCORE: 0.8663

RIG_SCORE: 0.7211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P40L	TCGA-06-1805	GBM	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	0.1667
p.P40L	DO11567	GBM	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.1667
p.R37C	TCGA-2W-A8YY	CESC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	0.25
p.R37C	DO223732	CESC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.25
p.R27C	TCGA-3B-A9I0	SARC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	0.8301
p.R27C	DO219940	SARC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.8301
p.A35V	TCGA-3N-A9WC	SKCM	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	0.3056
p.A35V	DO51234	SKCM	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.3056
p.R38H	TCGA-AX-A1C5	UCEC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	0.2222
p.R38H	DO41422	UCEC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.2222
p.K32N	TCGA-P3-A5QF	HNSC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	0.5806
p.K32N	DO44439	HNSC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.5806
p.R43H	DO225028	BRCA	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.0833
p.S31I	DO229008	LICA	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	0.623
p.I33T	SIDM01265	Plasma Cell Myeloma	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	0.7078
p.I33T	SIDM00650	Small Cell Lung Carcinoma	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	0.7078
p.I33T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	0.7078
p.I33T	SIDM01681	Non-Cancerous	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	0.7078
p.I33T	SIDM01318	Hepatocellular Carcinoma	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14807	Kinesin-like protein KIF22	DEG_APCC_DBOX_1	26:34	GRCRLSKIG	APC,CDC20,FZR1	0.893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons