DegronMD - Q14807(KIF22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P40L	TCGA-06-1805	GBM	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.P40L	TCGA-06-1805	GBM	TCGA	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.0556
p.P40L	DO11567	GBM	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.P40L	DO11567	GBM	ICGC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.0556
p.R264H	TCGA-06-5416	GBM	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.7133
p.R264H	TCGA-E7-A7DV	BLCA	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.7133
p.R264H	DO48583	BLCA	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.7133
p.R264H	DO10880	GBM	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.7133
p.R37C	TCGA-2W-A8YY	CESC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.R37C	DO223732	CESC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.A58V	TCGA-2W-A8YY	CESC	TCGA	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.25
p.A58V	TCGA-JY-A6FD	ESCA	TCGA	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.25
p.A58V	DO223732	CESC	ICGC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.25
p.V254L	TCGA-34-2600	LUSC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.1667
p.R27C	TCGA-3B-A9I0	SARC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.8301
p.R27C	DO219940	SARC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.8301
p.A35V	TCGA-3N-A9WC	SKCM	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.3056
p.A35V	DO51234	SKCM	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.3056
p.R257L	TCGA-46-3765	LUSC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.25
p.R257L	DO26959	LUSC	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.25
p.R45M	TCGA-A5-A0G2	UCEC	TCGA	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.1944
p.R45M	DO41235	UCEC	ICGC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.1944
p.R257W	TCGA-A5-A1OF	UCEC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.25
p.R466Q	TCGA-AA-3815	COAD	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation altering degron motif	0.6218
p.R466Q	DO9924	COAD	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation altering degron motif	0.6218
p.R466Q	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation altering degron motif	0.6218
p.R466Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation altering degron motif	0.6218
p.A60T	TCGA-AB-2828	LAML	TCGA	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.1944
p.A60T	DO21571	LAML	ICGC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.1944
p.V470M	TCGA-AP-A051	UCEC	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.25
p.V470M	DO42673	UCEC	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.25
p.R38H	TCGA-AX-A1C5	UCEC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.R38H	DO41422	UCEC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.L460V	TCGA-C5-A1MH	CESC	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation altering degron motif	0.5654
p.L460V	DO48982	CESC	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation altering degron motif	0.5654
p.P262L	TCGA-D3-A8GJ	SKCM	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.7582
p.R282Q	TCGA-DF-A2KU	UCEC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.0556
p.R282Q	DO223286	UCEC	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.0556
p.R468W	TCGA-NH-A5IV	COAD	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.3056
p.R468W	DO49095	COAD	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.3056
p.K32N	TCGA-P3-A5QF	HNSC	TCGA	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.5806
p.K32N	DO44439	HNSC	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.5806
p.R43H	DO225028	BRCA	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.0833
p.R43H	DO225028	BRCA	ICGC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.1389
p.E477A	DO233634	GACA	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.0556
p.A47S	DO228985	LICA	ICGC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.25
p.S31I	DO229008	LICA	ICGC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.623
p.Y58C	DO36839	READ	ICGC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.25
p.P279H	DO38016	SKCM	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.1389
p.I33T	SIDM01265	Plasma Cell Myeloma	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7078
p.I33T	SIDM00650	Small Cell Lung Carcinoma	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7078
p.I33T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7078
p.I33T	SIDM01681	Non-Cancerous	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7078
p.I33T	SIDM01318	Hepatocellular Carcinoma	GDSC	GRCRLSKIG	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7078
p.R51W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation altering degron motif	0.7523
p.R51W	ACH-002256	Leukemia	CCLE	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation altering degron motif	0.7523
p.R51W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation altering degron motif	0.7523
p.D280G	SIDM01045	Endometrial Carcinoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.1111
p.D280G	EN	endometrium	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.1111
p.C65S	SIDM00085	Glioma	GDSC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.0556
p.C65S	ACH-000655	Brain Cancer	CCLE	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.0556
p.C65S	SF268	central nervous system	COSMIC	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.0556
p.R266Q	SIDM00498	Colorectal Carcinoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.6218
p.R266Q	SNU-C5	large intestine	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.6218
p.E279K	SIDM01228	Melanoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.1389
p.E279K	ACH-000931	Skin Cancer	CCLE	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.1389
p.E279K	CHL-1	skin	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.1389
p.G268V	SIDM01320	Pancreatic Carcinoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation altering degron motif	0.6421
p.V46M	ACH-000122	Leukemia	CCLE	LRPFVD	LIG_APCC_ABBA_1	50:55	Mutation rewiring degron network	0.2222
p.L273P	ACH-000981	Leukemia	CCLE	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.3056
p.L273P	DND-41	haematopoietic and lymphoid tissue	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.3056
p.N477D	ACH-001211	Rhabdoid	CCLE	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.0556
p.R282H	LIM1215	large intestine	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	260:272	Mutation rewiring degron network	0.0556
p.Q472L	SJSA-1	bone	COSMIC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.1944
p.R450C	SNU-81	large intestine	COSMIC	LLSTPKRE	DEG_SCF_FBW7_2	460:467	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF22

UniProt ID: Q14807

Entrez ID: 3835

Protein name: Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF22 in