DegronMD

Uniprot ID: Q14807

Source protein: Kinesin-like protein KIF22

Source gene: KIF22

Class: DEG_ODPH_VHL_1

Location: 260:272

E3 ligase: VHL

DEGRON score: 0.7684

ASA_SCORE: 66.9615

COIL: 0.3686

CONS_SCORE: 0.6027

DSS_SCORE: 0.2693

HELIX: 0.0114

FCONS_SCORE: 0.8125

RIG_SCORE: 0.8083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R264H	TCGA-06-5416	GBM	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.7133
p.R264H	TCGA-E7-A7DV	BLCA	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.7133
p.R264H	DO48583	BLCA	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.7133
p.R264H	DO10880	GBM	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.7133
p.V254L	TCGA-34-2600	LUSC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.1667
p.R257L	TCGA-46-3765	LUSC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.25
p.R257L	DO26959	LUSC	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.25
p.R257W	TCGA-A5-A1OF	UCEC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.25
p.P262L	TCGA-D3-A8GJ	SKCM	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.7582
p.R282Q	TCGA-DF-A2KU	UCEC	TCGA	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.0556
p.R282Q	DO223286	UCEC	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.0556
p.P279H	DO38016	SKCM	ICGC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.1389
p.D280G	SIDM01045	Endometrial Carcinoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.1111
p.D280G	EN	endometrium	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.1111
p.R266Q	SIDM00498	Colorectal Carcinoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.6218
p.R266Q	SNU-C5	large_intestine	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.6218
p.E279K	SIDM01228	Melanoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.1389
p.E279K	ACH-000931	Skin Cancer	CCLE	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.1389
p.E279K	CHL-1	skin	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.1389
p.G268V	SIDM01320	Pancreatic Carcinoma	GDSC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.6421
p.L273P	ACH-000981	Leukemia	CCLE	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.3056
p.L273P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.3056
p.R282H	LIM1215	large_intestine	COSMIC	LAPFRQREGKLYL	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14807	Kinesin-like protein KIF22	DEG_ODPH_VHL_1	260:272	LAPFRQREGKLYL	VHL	0.7684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPFRQREGKLYL

Degron related mutations and impact score

Drug responses associated with KIF22 mutations

All proteins holding degron of LAPFRQREGKLYL