DegronMD

Uniprot ID: Q14807

Source protein: Kinesin-like protein KIF22

Source gene: KIF22

Class: DEG_SCF_FBW7_2

Location: 460:467

E3 ligase: FBXW7

DEGRON score: 0.9841

ASA_SCORE: 90.8875

COIL: 0.451

CONS_SCORE: 0.4299

DSS_SCORE: 0.495

HELIX: 0.5414

FCONS_SCORE: 1.1148

RIG_SCORE: 0.7081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R466Q	TCGA-AA-3815	COAD	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	0.6218
p.R466Q	DO9924	COAD	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	0.6218
p.R466Q	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LLSTPKRE	DEG_SCF_FBW7_2	0.6218
p.R466Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	LLSTPKRE	DEG_SCF_FBW7_2	0.6218
p.V470M	TCGA-AP-A051	UCEC	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	0.25
p.V470M	DO42673	UCEC	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	0.25
p.L460V	TCGA-C5-A1MH	CESC	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	0.5654
p.L460V	DO48982	CESC	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	0.5654
p.R468W	TCGA-NH-A5IV	COAD	TCGA	LLSTPKRE	DEG_SCF_FBW7_2	0.3056
p.R468W	DO49095	COAD	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	0.3056
p.E477A	DO233634	GACA	ICGC	LLSTPKRE	DEG_SCF_FBW7_2	0.0556
p.N477D	ACH-001211	Rhabdoid	CCLE	LLSTPKRE	DEG_SCF_FBW7_2	0.0556
p.Q472L	SJSA-1	bone	COSMIC	LLSTPKRE	DEG_SCF_FBW7_2	0.1944
p.R450C	SNU-81	large_intestine	COSMIC	LLSTPKRE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14807	Kinesin-like protein KIF22	DEG_SCF_FBW7_2	460:467	LLSTPKRE	FBXW7	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons