DegronMD

Uniprot ID: Q14807

Source protein: Kinesin-like protein KIF22

Source gene: KIF22

Class: LIG_APCC_ABBA_1

Location: 50:55

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9531

ASA_SCORE: 59.0833

COIL: 0.716

CONS_SCORE: 0.6706

DSS_SCORE: 0.3687

HELIX: 0.123

FCONS_SCORE: 1.2132

RIG_SCORE: 0.7803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P40L	TCGA-06-1805	GBM	TCGA	LRPFVD	LIG_APCC_ABBA_1	0.0556
p.P40L	DO11567	GBM	ICGC	LRPFVD	LIG_APCC_ABBA_1	0.0556
p.A58V	TCGA-2W-A8YY	CESC	TCGA	LRPFVD	LIG_APCC_ABBA_1	0.25
p.A58V	TCGA-JY-A6FD	ESCA	TCGA	LRPFVD	LIG_APCC_ABBA_1	0.25
p.A58V	DO223732	CESC	ICGC	LRPFVD	LIG_APCC_ABBA_1	0.25
p.R45M	TCGA-A5-A0G2	UCEC	TCGA	LRPFVD	LIG_APCC_ABBA_1	0.1944
p.R45M	DO41235	UCEC	ICGC	LRPFVD	LIG_APCC_ABBA_1	0.1944
p.A60T	TCGA-AB-2828	LAML	TCGA	LRPFVD	LIG_APCC_ABBA_1	0.1944
p.A60T	DO21571	LAML	ICGC	LRPFVD	LIG_APCC_ABBA_1	0.1944
p.R43H	DO225028	BRCA	ICGC	LRPFVD	LIG_APCC_ABBA_1	0.1389
p.A47S	DO228985	LICA	ICGC	LRPFVD	LIG_APCC_ABBA_1	0.25
p.Y58C	DO36839	READ	ICGC	LRPFVD	LIG_APCC_ABBA_1	0.25
p.R51W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRPFVD	LIG_APCC_ABBA_1	0.7523
p.R51W	ACH-002256	Leukemia	CCLE	LRPFVD	LIG_APCC_ABBA_1	0.7523
p.R51W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LRPFVD	LIG_APCC_ABBA_1	0.7523
p.C65S	SIDM00085	Glioma	GDSC	LRPFVD	LIG_APCC_ABBA_1	0.0556
p.C65S	ACH-000655	Brain Cancer	CCLE	LRPFVD	LIG_APCC_ABBA_1	0.0556
p.C65S	SF268	central_nervous_system	COSMIC	LRPFVD	LIG_APCC_ABBA_1	0.0556
p.V46M	ACH-000122	Leukemia	CCLE	LRPFVD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14807	Kinesin-like protein KIF22	LIG_APCC_ABBA_1	50:55	LRPFVD	APC,CDC20,FZR1	0.9531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons